共 68 条
GW182 family proteins are crucial for microRNA-mediated gene silencing
被引:91
作者:

Ding, Lei
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Howard Hughes Med Inst, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA

Han, Min
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Colorado, Howard Hughes Med Inst, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA Univ Colorado, Howard Hughes Med Inst, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA
机构:
[1] Univ Colorado, Howard Hughes Med Inst, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA
[2] Univ Michigan, Life Sci Inst 5435, Ann Arbor, MI 48109 USA
基金:
美国国家卫生研究院;
关键词:
D O I:
10.1016/j.tcb.2007.06.003
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
microRNAs (miRNAs) are a conserved class of small RNAs similar to 22 nucleotides in length. They regulate the expression of a large number of mRNAs in animals and plants through the miRNA-induced silencing complex (miRISQ. The conserved GW182 family of proteins has recently been identified, and its members have been shown to be associated with miRISC and to be required for miRNA-mediated gene silencing. These proteins have also been localized to processing bodies that are cytoplasmic messenger ribonucleoprotein (mRNP) aggregates containing mRNA decay factors, translational repressors and untranslated mRNAs. Therefore, these properties of GW182 family proteins support the hypothesis that the formation of untranslatable messenger ribonuclear protein particles is one important mechanism of miRNA-mediated gene silencing.
引用
收藏
页码:411 / 416
页数:6
相关论文
共 68 条
[1]
Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation
[J].
Bagga, S
;
Bracht, J
;
Hunter, S
;
Massirer, K
;
Holtz, J
;
Eachus, R
;
Pasquinelli, AE
.
CELL,
2005, 122 (04)
:553-563

Bagga, S
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

Bracht, J
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

Hunter, S
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

Massirer, K
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

Holtz, J
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

Eachus, R
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

Pasquinelli, AE
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA
[2]
Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies
[J].
Barbee, Scott A.
;
Estes, Patricia S.
;
Cziko, Anne-Marie
;
Hillebrand, Jens
;
Luedeman, Rene A.
;
Coller, Jeff M.
;
Johnson, Nick
;
Howlett, Iris C.
;
Geng, Cuiyun
;
Ueda, Ryu
;
Brand, Andrea H.
;
Newbury, Sarah F.
;
Wilhelm, James E.
;
Levine, Richard B.
;
Nakamura, Akira
;
Parker, Roy
;
Ramaswami, Mani
.
NEURON,
2006, 52 (06)
:997-1009

Barbee, Scott A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

Estes, Patricia S.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

Cziko, Anne-Marie
论文数: 0 引用数: 0
h-index: 0
机构: Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

Hillebrand, Jens
论文数: 0 引用数: 0
h-index: 0
机构: Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

Luedeman, Rene A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

Coller, Jeff M.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

Johnson, Nick
论文数: 0 引用数: 0
h-index: 0
机构: Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

Howlett, Iris C.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

Geng, Cuiyun
论文数: 0 引用数: 0
h-index: 0
机构: Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

Ueda, Ryu
论文数: 0 引用数: 0
h-index: 0
机构: Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

Brand, Andrea H.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

Newbury, Sarah F.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

Wilhelm, James E.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

Levine, Richard B.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

Nakamura, Akira
论文数: 0 引用数: 0
h-index: 0
机构: Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

Parker, Roy
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

论文数: 引用数:
h-index:
机构:
[3]
MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004)
[J].
Bartel, David P.
.
CELL,
2007, 131 (04)
:11-29

Bartel, David P.
论文数: 0 引用数: 0
h-index: 0
机构: Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
[4]
MRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes
[J].
Behm-Ansmant, Isabelle
;
Rehwinkel, Jan
;
Doerks, Tobias
;
Stark, Alexander
;
Bork, Peer
;
Izaurralde, Elisa
.
GENES & DEVELOPMENT,
2006, 20 (14)
:1885-1898

Behm-Ansmant, Isabelle
论文数: 0 引用数: 0
h-index: 0
机构: European Mol Biol Lab, D-69117 Heidelberg, Germany

Rehwinkel, Jan
论文数: 0 引用数: 0
h-index: 0
机构: European Mol Biol Lab, D-69117 Heidelberg, Germany

Doerks, Tobias
论文数: 0 引用数: 0
h-index: 0
机构: European Mol Biol Lab, D-69117 Heidelberg, Germany

Stark, Alexander
论文数: 0 引用数: 0
h-index: 0
机构: European Mol Biol Lab, D-69117 Heidelberg, Germany

Bork, Peer
论文数: 0 引用数: 0
h-index: 0
机构: European Mol Biol Lab, D-69117 Heidelberg, Germany

Izaurralde, Elisa
论文数: 0 引用数: 0
h-index: 0
机构:
European Mol Biol Lab, D-69117 Heidelberg, Germany European Mol Biol Lab, D-69117 Heidelberg, Germany
[5]
Relief of microRNA-mediated translational repression in human cells subjected to stress
[J].
Bhattacharyya, Suvendra N.
;
Habermacher, Regula
;
Martine, Ursula
;
Closs, Ellen I.
;
Filipowicz, Witold
.
CELL,
2006, 125 (06)
:1111-1124

Bhattacharyya, Suvendra N.
论文数: 0 引用数: 0
h-index: 0
机构: Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland

Habermacher, Regula
论文数: 0 引用数: 0
h-index: 0
机构: Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland

Martine, Ursula
论文数: 0 引用数: 0
h-index: 0
机构: Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland

Closs, Ellen I.
论文数: 0 引用数: 0
h-index: 0
机构: Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland

Filipowicz, Witold
论文数: 0 引用数: 0
h-index: 0
机构: Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland
[6]
The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis
[J].
Carmell, MA
;
Xuan, ZY
;
Zhang, MQ
;
Hannon, GJ
.
GENES & DEVELOPMENT,
2002, 16 (21)
:2733-2742

Carmell, MA
论文数: 0 引用数: 0
h-index: 0
机构: Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

Xuan, ZY
论文数: 0 引用数: 0
h-index: 0
机构: Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

Zhang, MQ
论文数: 0 引用数: 0
h-index: 0
机构: Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

Hannon, GJ
论文数: 0 引用数: 0
h-index: 0
机构: Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
[7]
Fragile X-related protein and VIG associate with the RNA interference machinery
[J].
Caudy, AA
;
Myers, M
;
Hannon, GJ
;
Hammond, SM
.
GENES & DEVELOPMENT,
2002, 16 (19)
:2491-2496

Caudy, AA
论文数: 0 引用数: 0
h-index: 0
机构:
Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA

Myers, M
论文数: 0 引用数: 0
h-index: 0
机构:
Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA

Hannon, GJ
论文数: 0 引用数: 0
h-index: 0
机构:
Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA

Hammond, SM
论文数: 0 引用数: 0
h-index: 0
机构:
Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
[8]
A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development
[J].
Chen, XM
.
SCIENCE,
2004, 303 (5666)
:2022-2025

Chen, XM
论文数: 0 引用数: 0
h-index: 0
机构:
Rutgers State Univ, Waksman Inst, Piscataway, NJ 08854 USA Rutgers State Univ, Waksman Inst, Piscataway, NJ 08854 USA
[9]
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
[J].
Chendrimada, TP
;
Gregory, RI
;
Kumaraswamy, E
;
Norman, J
;
Cooch, N
;
Nishikura, K
;
Shiekhattar, R
.
NATURE,
2005, 436 (7051)
:740-744

Chendrimada, TP
论文数: 0 引用数: 0
h-index: 0
机构:
Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

Gregory, RI
论文数: 0 引用数: 0
h-index: 0
机构:
Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

Kumaraswamy, E
论文数: 0 引用数: 0
h-index: 0
机构:
Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

Norman, J
论文数: 0 引用数: 0
h-index: 0
机构:
Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

Cooch, N
论文数: 0 引用数: 0
h-index: 0
机构:
Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

Nishikura, K
论文数: 0 引用数: 0
h-index: 0
机构:
Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

Shiekhattar, R
论文数: 0 引用数: 0
h-index: 0
机构:
Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA
[10]
Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54
[J].
Chu, Chia-ying
;
Rana, Tariq M.
.
PLOS BIOLOGY,
2006, 4 (07)
:1122-1136

Chu, Chia-ying
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA USA Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA USA

Rana, Tariq M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA USA Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA USA