GW182 family proteins are crucial for microRNA-mediated gene silencing

被引:91
作者
Ding, Lei
Han, Min [1 ]
机构
[1] Univ Colorado, Howard Hughes Med Inst, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA
[2] Univ Michigan, Life Sci Inst 5435, Ann Arbor, MI 48109 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/j.tcb.2007.06.003
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
microRNAs (miRNAs) are a conserved class of small RNAs similar to 22 nucleotides in length. They regulate the expression of a large number of mRNAs in animals and plants through the miRNA-induced silencing complex (miRISQ. The conserved GW182 family of proteins has recently been identified, and its members have been shown to be associated with miRISC and to be required for miRNA-mediated gene silencing. These proteins have also been localized to processing bodies that are cytoplasmic messenger ribonucleoprotein (mRNP) aggregates containing mRNA decay factors, translational repressors and untranslated mRNAs. Therefore, these properties of GW182 family proteins support the hypothesis that the formation of untranslatable messenger ribonuclear protein particles is one important mechanism of miRNA-mediated gene silencing.
引用
收藏
页码:411 / 416
页数:6
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