G2/M cell cycle arrest in the life cycle of viruses

被引:126
作者
Davy, Clare [1 ]
Doorbar, John [1 ]
机构
[1] Natl Inst Med Res, Div Virol, London NW7 1AA, England
基金
英国医学研究理事会;
关键词
G2/M arrest; HPV; HIV; life cycle; replication;
D O I
10.1016/j.virol.2007.05.043
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
There is increasing evidence that viral infection, expression of viral protein or the presence of viral DNA causes the host cell cycle to arrest during G2/M. The mechanisms used by viruses to cause arrest vary widely; some involve the activation of the cellular pathways that induce arrest in response to DNA damage, while others use completely novel means. The analysis of virus-mediated arrest has not been proven easy, and in most cases the consequences of arrest for the virus life cycle are not well defined. However, a number of effects of arrest are being investigated and it will be interesting to see to what extent perturbation of the G2/M transition is involved in viral infections. Crown Copyright (c) 2007 Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:219 / 226
页数:8
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