G2/M cell cycle arrest in the life cycle of viruses

被引：126

作者：

Davy, Clare ^{[1
]}

Doorbar, John ^{[1
]}

机构：

[1] Natl Inst Med Res, Div Virol, London NW7 1AA, England

来源：

VIROLOGY | 2007年 / 368卷 / 02期

基金：

英国医学研究理事会;

关键词：

G2/M arrest; HPV; HIV; life cycle; replication;

D O I：

10.1016/j.virol.2007.05.043

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

There is increasing evidence that viral infection, expression of viral protein or the presence of viral DNA causes the host cell cycle to arrest during G2/M. The mechanisms used by viruses to cause arrest vary widely; some involve the activation of the cellular pathways that induce arrest in response to DNA damage, while others use completely novel means. The analysis of virus-mediated arrest has not been proven easy, and in most cases the consequences of arrest for the virus life cycle are not well defined. However, a number of effects of arrest are being investigated and it will be interesting to see to what extent perturbation of the G2/M transition is involved in viral infections. Crown Copyright (c) 2007 Published by Elsevier Inc. All rights reserved.

引用

页码：219 / 226

页数：8

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