Versatile and stereloselective syntheses of orthogonally protected β-methylcysteine and β-methyllanthionine

被引：61

作者：

Narayan, RS ^{[1
]}

VanNieuwenhze, MS ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 13期

关键词：

D O I：

10.1021/ol0507930

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lantibiotics are a class of lanthionine (and/or beta-methyllanthionine)-containing peptides with antibioitic activity against Gram-positive bacteria. As part of our research effort directed toward the synthesis and mechanistic study of the lantibiotic peptide mersacidin (1), we report stereoselective syntheses of orthogonally protected beta-methylcysteine (beta-MeCys) and,beta-methyllanthionine (beta-MeLan), two key nonnatural amino acid components of the mersacidin architecture.

引用

页码：2655 / 2658

页数：4

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