Alignment of long DNA molecules on templates generated via dip-pen nanolithography

被引：43

作者：

Nyamjav, D

Ivanisevic, A

机构：

[1] Purdue Univ, Dept Biomed Engn, W Lafayette, IN 47907 USA

[2] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[3] Purdue Univ, Dept Phys, W Lafayette, IN 47907 USA

来源：

ADVANCED MATERIALS | 2003年 / 15卷 / 21期

关键词：

D O I：

10.1002/adma.200305342

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A methodology to place and stretch long DNA molecules by coupling dip-pen nanolithography with molecular combing is presented. Templates were fabricated on SiOx surfaces using a positively charged polymer, poly(allylamine hydrochloride). Upon molecular combing, DNA molecules elongate on the surface (for example, see Figure) and are localized by the presence of the charged lithographically defined structures.

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页码：1805 / 1809

页数：5

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