Expression of copper trafficking genes in the mouse brain

被引：52

作者：

Nishihara, E

Furuyama, T

Yamashita, S

Mori, N

机构：

[1] Natl Inst Longev Sci, Dept Mol Genet Res, Aichi 4748522, Japan

[2] Nagasaki Univ, Sch Med, Dept Nat Med, Atom Bomb Dis Inst, Nagasaki 8528102, Japan

来源：

NEUROREPORT | 1998年 / 9卷 / 14期

关键词：

ATP7a; ATX1; CCS; copper; COX17; choroid plexus; CTR1;

D O I：

10.1097/00001756-199810050-00023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

COPPER homeostasis in the brain must be strictly maintained, since copper is an essential trace element and is potentially toxic. To understand the mechanism of copper homeostasis in the brain, we cloned several mouse homologues of copper trafficking genes and performed in situ hybridization histochemistry. mCTR1, mATX1, and mATP7a were highly expressed in the choroid plexus, indicating that the choroid plexus uses the trafficking pathway from uptake to efflux to transport copper to the cerebrospinal fluids. We suggest that these genes may regulate copper concentration in the brain through the choroid plexus. (C) 1998 Lippincott Williams & Wilkins.

引用

页码：3259 / 3263

页数：5

共 22 条

[1] Isolation of a cDNA encoding the human homolog of COX17, a yeast gene essential for mitochondrial copper recruitment
Amaravadi, R
Glerum, DM
Tzagoloff, A
[J]. HUMAN GENETICS, 1997, 99 (03) : 329 - 333
[2] The copper chaperone for superoxide dismutase
Culotta, VC
Klomp, LWJ
Strain, J
Casareno, RLB
Krems, B
Gitlin, JD
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (38) : 23469 - 23472
[3] DANCIS A, 1994, J BIOL CHEM, V269, P25660
[4] Danks DM, 1989, METABOLIC BASIS INHE, P1411
[5] Immunocytochemical localization of the Menkes copper transport protein (ATP7A) to the trans-Golgi network
Dierick, HA
Adam, AN
EscaraWilke, JF
Glover, TW
[J]. HUMAN MOLECULAR GENETICS, 1997, 6 (03) : 409 - 416
[6] BIOCHEMICAL-STUDY ON THE CRITICAL PERIOD FOR TREATMENT OF THE MOTTLED BRINDLED MOUSE
FUJII, T
ITO, M
TSUDA, H
MIKAWA, H
[J]. JOURNAL OF NEUROCHEMISTRY, 1990, 55 (03) : 885 - 889
[7] Ghadge GD, 1997, J NEUROSCI, V17, P8756
[8] Characterization of COX17, a yeast gene involved in copper metabolism and assembly of cytochrome oxidase
Glerum, DM
Shtanko, A
Tzagoloff, A
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (24) : 14504 - 14509
[9] CLONING AND CHARACTERIZATION OF THE SACCHAROMYCES-CEREVISIAE LYS7 GENE - EVIDENCE FOR FUNCTION OUTSIDE OF LYSINE BIOSYNTHESIS
HORECKA, J
KINSEY, PT
SPRAGUE, GF
[J]. GENE, 1995, 162 (01) : 87 - 92
[10] IDENTIFICATION OF A MEMBER OF MOUSE SEMAPHORIN FAMILY
INAGAKI, S
FURUYAMA, T
IWAHASHI, Y
[J]. FEBS LETTERS, 1995, 370 (03) : 269 - 272

← 1 2 3 →