Pure, homo-bifunctional poly(ethylene glycol) orthogonally protected: synthesis and characterisation

被引：12

作者：

Drioli, S ^{[1
]}

Benedetti, F ^{[1
]}

Bonora, GM ^{[1
]}

机构：

[1] Univ Trieste, Dipartimento Sci Chim, I-34127 Trieste, Italy

来源：

REACTIVE & FUNCTIONAL POLYMERS | 2001年 / 48卷 / 1-3期

关键词：

poly(ethylene glycol); protection; purification; NMR; mass spectrometry;

D O I：

10.1016/S1381-5148(01)00044-X

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

New orthogonal reversible protections have been introduced on high-molecular weight, di-hydroxy PEGs. The introduction on the reaction intermediates of a removable carboxy group allows an efficient purification from all the undesired polymeric derivatives. A final, pure high-molecular weight DMT-PEG-Fmoc has been obtained. (C) 2001 Elsevier Science B.V; All rights reserved.

引用

页码：119 / 128

页数：10

共 17 条

[1]

Agrawal S., 1996, ANTISENSE THERAPEUTI

[2]

[Anonymous], POLY ETHYLENE GLYCOL

[3] Peptide-oligonucleotide phosphorothioate conjugates with membrane translocation and nuclear localization properties [J].