Daptomycin exerts bactericidal activity without lysis of Staphylococcus aureus

被引：103

作者：

Cotroneo, Nicole ^{[1
]}

Harris, Robert ^{[2
]}

Perlmutter, Nancy

Beveridge, Terry ^{[2
,3
]}

Silverman, Jared A. ^{[1
]}

机构：

[1] Cubist Pharmaceut Inc, Lexington, MA 02421 USA

[2] Univ Guelph, Guelph, ON N1G 2W1, Canada

[3] MicroTEM Inc, Elora, ON N0B 1S0, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 06期

关键词：

D O I：

10.1128/AAC.01410-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The ability of daptomycin to produce bactericidal activity against Staphylococcus aureus while causing negligible cell lysis has been demonstrated using electron microscopy and the membrane integrity probes calcein and ToPro3. The formation of aberrant septa on the cell wall, suggestive of impairment of the cell division machinery, was also observed.

引用

收藏

页码：2223 / 2225

页数：3

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