The A1 allele of the D2 dopamine receptor gene is associated with high dopamine transporter density in detoxified alcoholics

被引：25

作者：

Laine, TPJ ^{[1
]}

Ahonen, A

Räsänen, P

Pohjalainen, T

Tiihonen, J

Hietala, J

机构：

[1] Univ Oulu, Dept Psychiat, FIN-900220 Oulu, Finland

[2] Univ Oulu, Dept Nucl Med, FIN-900220 Oulu, Finland

[3] Univ Helsinki, Dept Clin Physiol & Nucl Med, FIN-00029 Helsinki, Finland

[4] Univ Turku, Dept Pharmacol, FIN-20520 Turku, Finland

[5] Univ Kuopio, Dept Forens Psychiat, FIN-70210 Kuopio, Finland

[6] Univ Kuopio, Dept Neurophysiol, FIN-70210 Kuopio, Finland

[7] Univ Turku, Dept Psychiat, Turku PET Ctr, FIN-20520 Turku, Finland

来源：

ALCOHOL AND ALCOHOLISM | 2001年 / 36卷 / 03期

关键词：

D O I：

10.1093/alcalc/36.3.262

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

The Al allele of TaqI A restriction fragment length polymorphism (RFLP) in the D-2 receptor (DRD2) gene locus has been suggested to be associated with low D-2 receptor density in man. Striatal dopamine transporter (DAT) densities were studied with [I-123]2-beta -carbometoxy-3 beta (4-iodophenyl)tropane and single-photon emission tomography in 29 detoxified alcoholics, who were also genotyped for the two alleles of TaqI A RFLP at the DRD2 receptor gene locus. Alcoholics with the A1/A2 genotypes (n = 10) had statistically significantly higher DAT densities than subjects with the A2/A2 genotypes [n = 19; 8.0 +/- 1.2 (mean +/- SD) vs 6.9 +/- 1.1, P = 0.035]. We suggest that the TaqI A RFLP is in linkage disequilibrium with a gene variant modifying DAT density in alcoholics.

引用

页码：262 / 265

页数：4

共 28 条

[21]

NOBLE EP, 1991, ARCH GEN PSYCHIAT, V48, P648

[22] The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers [J].

Pohjalainen, T ;

Rinne, JO ;

Nagren, K ;

Lehikoinen, P ;

Anttila, K ;

Syvalahti, EKG ;

Hietala, J .

MOLECULAR PSYCHIATRY, 1998, 3 (03) :256-260

[23]

Scheffel U, 1996, SYNAPSE, V23, P61

[24]

Seibyl JP, 1996, J NUCL MED, V37, P222

[25] D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele [J].

Thompson, J ;

Thomas, N ;

Singleton, A ;

Piggott, M ;

Lloyd, S ;

Perry, EK ;

Morris, CM ;

Perry, RH ;

Ferrier, IN ;

Court, JA .

PHARMACOGENETICS, 1997, 7 (06) :479-484

[26] BLOT HYBRIDIZATION ANALYSIS OF GENOMIC DNA [J].

VANDENPLAS, S ;

WIID, I ;

GROBLERRABIE, A ;

BREBNER, K ;

RICKETTS, M ;

WALLIS, G ;

BESTER, A ;

BOYD, C ;

MATHEW, C .

JOURNAL OF MEDICAL GENETICS, 1984, 21 (03) :164-172

[27]

Volkow ND, 1996, J NUCL MED, V37, P554

[28] Decreases in dopamine receptors but not in dopamine transporters in alcoholics [J].

Volkow, ND ;

Wang, GJ ;

Fowler, JS ;

Logan, J ;

Hitzemann, R ;

Ding, YS ;

Pappas, N ;

Shea, C ;

Piscani, K .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1996, 20 (09) :1594-1598

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