Bcl-2 is not required in retinal ganglion cells surviving optic nerve axotomy

被引：17

作者：

Dietz, GPH ^{[1
]}

Kilic, E ^{[1
]}

Bähr, M ^{[1
]}

Isenmann, S ^{[1
]}

机构：

[1] Dept Neurol, D-72076 Tubingen, Germany

来源：

NEUROREPORT | 2001年 / 12卷 / 15期

关键词：

animal model; apoptosis; bcl-2; in vivo; knockout mouse; null mutation; optic nerve injury; neurodegeneration; retinal ganglion cell; retinotectal;

D O I：

10.1097/00001756-200110290-00041

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Axotomy of the optic nerve in rodents induces the majority of retinal ganglion cells (RGCs) to undergo apoptosis: Only 10-15% survive 14 days past lesion. The molecular mechanism allowing this survival is not known. To test whether expression of the anti-apoptotic proto-oncogene bcl-2 gene is required in those RGCs, we examined the effect of optic nerve axotomy in bcl-2(-/-) mice. 7 days and 14 days post-lesion, the same number of surviving RGCs was detected in mutant and wild type retinas. Thus, the bcl-2 gene is not necessary for the survival of the subpopulation of retinal ganglion cells resisting axotomy-induced apoptosis in adult mice, nor does its normal expression delay retinal ganglion cell degeneration. NeuroReport 12:3353-3356 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：3353 / 3356

页数：4

共 17 条

[11] C-ELEGANS CELL-SURVIVAL GENE CED-9 ENCODES A FUNCTIONAL HOMOLOG OF THE MAMMALIAN PROTOONCOGENE BCL-2 [J].