Preparation and characterization of poly(ethylene glycol)-g-chitosan with water- and organosolubility

被引：58

作者：

Hu, YQ ^{[1
]}

Jiang, HL ^{[1
]}

Xu, CN ^{[1
]}

Wang, YJ ^{[1
]}

Zhu, KJ ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Polymer Sci & Engn, Hangzhou 310027, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2005年 / 61卷 / 04期

基金：

中国国家自然科学基金;

关键词：

chitosan; poly(ethylene glycol); graft copolymer; PEG-g-chitosan; solubility;

D O I：

10.1016/j.carbpol.2005.06.022

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new scheme was proposed for synthesizing poly(ethylene glycol)-g-chitosan (PEG-g-CS), where methoxy poly(ethylene glycol) iodide (MPEG-I) (M. 2000) was used for N-substitution of triphenylmethyl chitosan (TPM-CS) in organic medium. The graft copolymers were obtained by subsequent removal of protecting groups with dichloroacetic acid. By varying PEG-I/TPM-CS feed ratio, the grafting levels (GL) of PEG can be adjusted. The chitosan derivatives were characterized by IFTIR, H-1 NMR, C-13 NMR and DSC. All the copolymers were soluble in water over wide pH range. Furthermore, organosolubility of the hybrids in DMF and DMSO was also achieved when the DS value more than 24%. The lysozyme degradation rate of the copolymers in aqueous neutral medium decreased with the increase of GL value. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：472 / 479

页数：8

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