The HIF pathway in cancer

被引：156

作者：

Maxwell, PH ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Renal Sect, London W12 0NN, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2005年 / 16卷 / 4-5期

基金：

英国惠康基金;

关键词：

HIF; VHL; hypoxia; cancer; angiogenesis;

D O I：

10.1016/j.semcdb.2005.03.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The transcription factor hypoxia-inducible factor-1 (HIF) is commonly activated in cancer. This has major effects on gene expression, and is important in tumor angiogenesis. Besides being activated by low oxygen, genetic events in cancer contribute to activating HIF. Most striking is that loss of function of the VHL tumour suppressor protein results in constitutive activation of the HIF pathway. An important aim is to define the contribution of HIF activation to the evolution of different cancers, and its potential as a therapeutic target. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：523 / 530

页数：8

共 66 条

[61]

VAUX EC, 2001, J BIOL CHEM, V12, P12

[62] HYPOXIA-INDUCIBLE FACTOR-1 IS A BASIC-HELIX-LOOP-HELIX-PAS HETERODIMER REGULATED BY CELLULAR O-2 TENSION [J].

WANG, GL ;

JIANG, BH ;

RUE, EA ;

SEMENZA, GL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (12) :5510-5514

[63]

WAX SD, 1994, J BIOL CHEM, V269, P13041

[64]

Wiesener MS, 2001, CANCER RES, V61, P5215

[65]

WIESNER MS, 2002, FASEB J

[66] PREDISPOSITION TO RENAL-CARCINOMA IN THE EKER RAT IS DETERMINED BY GERM-LINE MUTATION OF THE TUBEROUS-SCLEROSIS-2 (TSC2) GENE [J].

YEUNG, RS ;

XIAO, GH ;

JIN, F ;

LEE, WC ;

TESTA, JR ;

KNUDSON, AG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (24) :11413-11416

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