Aerosol bolus dispersion in healthy subjects

被引:51
作者
Brand, P [1 ]
Rieger, C [1 ]
Schulz, H [1 ]
Beinert, T [1 ]
Heyder, J [1 ]
机构
[1] GSF FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT, INST INHALAT BIOL, OBERSCHLEISSHEIM, GERMANY
关键词
aerosol bolus dispersion; convective gas mixing; flow rate; healthy subjects; lung inflation; ventilatory inhomogeneities;
D O I
10.1183/09031936.97.10020460
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Aerosol bolus dispersion is a physiological test of lungs, which uses monodisperse submicron particles to measure intrapulmonary convective gas mixing, In this study, aerosol bolus dispersion was measured in healthy subjects in order to assess reference values for possible clinical applications, to assess the reproducibility of these values, and to identify physical and physiological factors influencing aerosol bolus dispersion. Aerosol bolus dispersion was measured in 79 healthy subjects using 20 cm(3) aerosol boluses consisting of monodisperse di-2-ethylhexyl sebacate (DEHS) particles. The reproducibility of parameters characterizing the width of the exhaled bolus was of the same order as that of parameters of the flow-volume curve (10%), Aerosol bolus dispersion mas independent of the level of lung inflation, and the slope of the relationship between flow rate and dispersion was on average not significantly different from zero (range 100-700 cm(3) . s(-1)). Multiple linear regression showed that aerosol bolus dispersion increased with increasing total lung capacity of the subject. We conclude that differences in total lung capacity between individuals should be taken into account when using measures of aerosol bolus dispersion for possible clinical applications.
引用
收藏
页码:460 / 467
页数:8
相关论文
共 28 条
[1]   INTRAPULMONARY MIXING OF GASES STUDIED WITH AEROSOLS [J].
ALTSHULER, B ;
PALMES, ED ;
YARMUS, L ;
NELSON, N .
JOURNAL OF APPLIED PHYSIOLOGY, 1959, 14 (03) :321-327
[2]   EFFECT OF CYSTIC-FIBROSIS ON INHALED AEROSOL BOLUSES [J].
ANDERSON, PJ ;
BLANCHARD, JD ;
BRAIN, JD ;
FELDMAN, HA ;
MCNAMARA, JJ ;
HEYDER, J .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1989, 140 (05) :1317-1324
[3]   UNEVEN VENTILATION IN SMOKERS [J].
BANERJEE, M ;
EVANS, JN ;
JAEGER, MJ .
RESPIRATION PHYSIOLOGY, 1976, 27 (03) :277-291
[4]   NOTES ON THE DIFFUSION-TYPE MODEL FOR LONGITUDINAL MIXING IN FLOW [J].
BISCHOFF, KB .
CHEMICAL ENGINEERING SCIENCE, 1960, 12 (01) :69-70
[5]   Aerosol bolus dispersion and aerosol-derived airway morphometry: Assessment of lung pathology and response to therapy .1. [J].
Blanchard, JD .
JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG, 1996, 9 (02) :183-205
[6]   DETECTION OF EARLY LUNG IMPAIRMENT WITH AEROSOL BOLUS DISPERSION [J].
BRAND, P ;
TUCH, T ;
MANUWALD, O ;
BISCHOF, W ;
HEINRICH, J ;
WICHMANN, HE ;
BEINERT, T ;
HEYDER, J .
EUROPEAN RESPIRATORY JOURNAL, 1994, 7 (10) :1830-1838
[7]   AEROSOL DERIVED AIRWAY MORPHOMETRY IN HEALTHY-SUBJECTS [J].
BRAND, P ;
RIEGER, C ;
BEINERT, T ;
HEYDER, J .
EUROPEAN RESPIRATORY JOURNAL, 1995, 8 (10) :1639-1646
[8]   FLOW DISTRIBUTION THROUGH HUMAN AND CANINE AIRWAYS DURING INHALATION AND EXHALATION [J].
BRIANT, JK ;
COHEN, BS .
JOURNAL OF APPLIED PHYSIOLOGY, 1989, 67 (04) :1649-1654
[9]   THEORETICAL DISCUSSION OF DIFFUSION AND CONVECTION IN LUNG [J].
CHANG, DB ;
LEWIS, SM ;
YOUNG, AC .
MATHEMATICAL BIOSCIENCES, 1976, 29 (3-4) :331-349
[10]   Two- and three-dimensional simulations of aerosol transport and deposition in alveolar zone of human lung [J].
Darquenne, C ;
Paiva, N .
JOURNAL OF APPLIED PHYSIOLOGY, 1996, 80 (04) :1401-1414