Rotavirus Vaccine Take in Infants Is Associated With Secretor Status

被引：36

作者：

Armah, George E. ^{[1
]}

Cortese, Margaret M. ^{[2
]}

Dennis, Francis E. ^{[1
]}

Yu, Ying ^{[3
]}

Morrow, Ardythe L. ^{[3
]}

McNeal, Monica M. ^{[4
]}

Lewis, Kristen D. C. ^{[5
]}

Awuni, Denis A. ^{[6
]}

Armachie, Joseph ^{[1
]}

Parashar, Umesh D. ^{[2
]}

机构：

[1] Univ Ghana, Noguchi Mem Inst Med Res, Legon, Ghana

[2] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA

[3] Cincinnati Childrens Hosp Med Ctr, Perinatal Inst, Dept Pediat, Cincinnati, OH 45229 USA

[4] Cincinnati Childrens Hosp Med Ctr, Div Infect Dis, Cincinnati, OH 45229 USA

[5] PPD, San Diego, CA USA

[6] Minist Hlth, Navrongo Hlth Res Ctr, Accra, Ghana

来源：

JOURNAL OF INFECTIOUS DISEASES | 2019年 / 219卷 / 05期

关键词：

secretor; rotavirus; vaccine; FUT2; Lewis antigen; BLOOD; INFECTION;

D O I：

10.1093/infdis/jiy573

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Rotaviruses bind to enterocytes in a genotype-specific manner via histo-blood group antigens (HBGAs), which are also detectable in saliva. We evaluated antirotavirus immunoglobulin A seroconversion (vaccine take) among 166 Ghanaian infants after 2-3 doses of G1P[8] rotavirus vaccine during a vaccine trial, by HBGA status from saliva collected at age 4.1 years. Only secretor status was associated with seroconversion: 41% seroconversion for secretors vs 13% for nonsecretors; relative risk, 3.2 (95% confidence interval, 1.2-8.1; P = .016). Neither Lewis antigen nor salivary antigen blood type was associated with seroconversion. Likelihood of take for any particular rotavirus vaccine may differ across populations based on HBGAs. Infants who are nonsecretors were about one-third as likely to have a serum antibody response after receiving oral G1P[8] rotavirus vaccine than secretors. Likelihood of take for any particular rotavirus vaccine may differ across populations based on histo-blood group antigens.

引用

页码：746 / 749

页数：4

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