The Role of Mitochondria in Brain Aging and the Effects of Melatonin

被引：45

作者：

Escames, Germaine ^{[1
,2
]}

Lopez, Ana ^{[1
,2
]}

Antonio Garcia, Jose ^{[1
,2
]}

Garcia, Laura ^{[1
,2
]}

Acuna-Castroviejo, Dario ^{[1
,2
,3
]}

Joaquin Garcia, Jose ^{[4
]}

Carlos Lopez, Luis ^{[1
,2
]}

机构：

[1] Univ Granada, Ctr Invest Biomed, Inst Biotecnol, E-18100 Granada, Spain

[2] Univ Granada, Fac Med, Dept Fisiol, E-18100 Granada, Spain

[3] Hosp Univ San Cecilio, Serv Anal Clin, Granada, Spain

[4] Fac Med, Dept Fisiol & Farmacol, Zaragoza, Spain

来源：

CURRENT NEUROPHARMACOLOGY | 2010年 / 8卷 / 03期

关键词：

Melatonin; mitochondria; oxidative stress; brain; aging; neurodegenerative diseases; neural stem cells; NEURAL STEM-CELLS; NITRIC-OXIDE SYNTHASE; AMYLOID BETA-PEPTIDE; AGE-RELATED DECLINE; SUPEROXIDE-DISMUTASE ACTIVITY; ACCELERATED MOUSE SAM; OXIDATIVE STRESS; HUNTINGTONS-DISEASE; DENTATE GYRUS; ALZHEIMERS-DISEASE;

D O I：

10.2174/157015910792246245

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Melatonin is an endogenous indoleamine present in different tissues, cellular compartments and organelles including mitochondria. When melatonin is administered orally, it is readily available to the brain where it counteracts different processes that occur during aging and age-related neurodegenerative disorders. These aging processes include oxidative stress and oxidative damage, chronic and acute inflammation, mitochondrial dysfunction and loss of neural regeneration. This review summarizes age related changes in the brain and the importance of oxidative/nitrosative stress and mitochondrial dysfunction in brain aging. The data and mechanisms of action of melatonin in relation to aging of the brain are reviewed as well.

引用

页码：182 / 193

页数：12

共 175 条

[1] Åberg MAI, 2000, J NEUROSCI, V20, P2896
[2] Expanding insights of mitochondrial dysfunction in Parkinson's disease
Abou-Sleiman, PM
Muqit, MMK
Wood, NW
[J]. NATURE REVIEWS NEUROSCIENCE, 2006, 7 (03) : 207 - 219
[3] ACUNA CD, 2002, CURR TOP MED CHEM, V2, P133, DOI DOI 10.2174/1568026023394344]
[4] Acuña-Castroviejo D, 2003, ADV EXP MED BIOL, V527, P549
[5] Melatonin and nitric oxide -: Two required antagonists for mitochondrial homeostasis
Acuña-Castroviejo, D
Escames, G
López, LC
Hitos, AB
León, J
[J]. ENDOCRINE, 2005, 27 (02) : 159 - 168
[6] Melatonin, mitochondria, and cellular bioenergetics
Acuña-Castroviejo, D
Martín, M
Macías, M
Escames, G
León, J
Khaldy, H
Reiter, RJ
[J]. JOURNAL OF PINEAL RESEARCH, 2001, 30 (02) : 65 - 74
[7] Acuna-Castroviejo D., 1997, Life Sci, V60, pPL23
[8] Melatonin role in the mitochondrial function
Acuna-Castroviejo, Dario
Escames, Germaine
Rodriguez, Maria I.
Lopez, Luis C.
[J]. FRONTIERS IN BIOSCIENCE-LANDMARK, 2007, 12 : 947 - 963
[9] Differential oxidative damage to mitochondrial proteins during aging
Agarwal, S
Sohal, RS
[J]. MECHANISMS OF AGEING AND DEVELOPMENT, 1995, 85 (01) : 55 - 63
[10] Andersen HR, 1997, CLIN CHEM, V43, P562

← 1 2 3 4 5 6 7 8 9 10 →