Total synthesis of (-)-tamandarin B

被引：28

作者：

Joullié, MM ^{[1
]}

Portonovo, P ^{[1
]}

Liang, B ^{[1
]}

Richard, DJ ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 49期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(00)01409-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of tamandarin B is described. Key steps in the synthesis of the macrocycle component include a diastereoselective ketone reduction, linear precursor formation via an activated pentafluorophenyl ester, and HATU-promoted cyclization. Side-chain coupling was achieved in excellent yield with the newly developed coupling reagent DEPBT. (C) 2000 Published by Elsevier Science Ltd.

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收藏

页码：9373 / 9376

页数：4

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