Segmental determination of ethyl glucuronide in hair: A pilot study

被引：104

作者：

Appenzeller, Brice M. R.

Agirman, Resmi

Neuberg, Paul

Yegles, Michel

Wennig, Robert

机构：

[1] Univ Luxemberg, Toxicol Lab, Ctr Rech Publ Sante, Lab Natl Sante, L-1511 Luxembourg, Luxembourg

[2] Ctr Hosp Neuro Psychiat, Ctr Therapeut Useldange, L-8707 Useldange, Luxembourg

来源：

FORENSIC SCIENCE INTERNATIONAL | 2007年 / 173卷 / 2-3期

关键词：

ethyl glucuronide; hair segmental analysis; alcohol consumption;

D O I：

10.1016/j.forsciint.2007.01.025

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Ethyl glucuronide (EtG) is a minor metabolite of ethanol. Its detection in hair is more and more studied in both clinical and forensic context for the purpose of alcohol abuse monitoring. In this pilot study, hair specimens from 15 patients included in a treatment program after alcohol abuse cessation, were segmented and analyzed for EtG. The results were then compared to their self-reported past alcohol consumption and to their blood biomarkers values (GGT, MCV, ASAT, ALAT). EtG concentrations measured in hair varied from 8 to 261 pg/mg. The pattern of EtG concentration detected in the different hair segments matched with the drinking history of patients, displaying variations (increase and decrease) in alcohol consumption and also time of cessation. Results also demonstrated the existence of a significant correlation (r(p) = 0.5357; p = 0.0390) between EtG concentration in hair and the amount of alcohol intake. Variations in the EtG concentrations with respect to hair segments may provide an overview of the drinking history of patients. Moreover, EtG concentration in hair may help to estimate the daily alcohol intake. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：87 / 92

页数：6

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