Mitochondrial Dynamics in Diabetes

被引：172

作者：

Yoon, Yisang ^{[1
,2
,3
]}

Galloway, Chad A. ^{[1
,3
]}

Jhun, Bong Sook ^{[1
,3
]}

Yu, Tianzheng ^{[4
]}

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Anesthesiol, Rochester, NY 14642 USA

[2] Univ Rochester, Sch Med & Dent, Dept Physiol & Pharmacol, Rochester, NY 14642 USA

[3] Univ Rochester, Sch Med & Dent, Mitochondrial Res & Innovat Grp, Rochester, NY 14642 USA

[4] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2011年 / 14卷 / 03期

基金：

美国国家卫生研究院;

关键词：

HUMAN SKELETAL-MUSCLE; DIFFERENTIATION-ASSOCIATED PROTEIN-1; DOMINANT OPTIC ATROPHY; PANCREATIC BETA-CELLS; CYTOCHROME-C RELEASE; IMPAIRED INSULIN-SECRETION; MARIE-TOOTH-DISEASE; M-AAA PROTEASE; MAMMALIAN-CELLS; OXIDATIVE STRESS;

D O I：

10.1089/ars.2010.3286

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria are at the center of cellular energy metabolism and regulate cell life and death. The cell biological aspect of mitochondria, especially mitochondrial dynamics, has drawn much attention through implications in human pathology, including neurological disorders and metabolic diseases. Mitochondrial fission and fusion are the main processes governing the morphological plasticity and are controlled by multiple factors, including mechanochemical enzymes and accessory proteins. Emerging evidence suggests that mitochondrial dynamics plays an important role in metabolism-secretion coupling in pancreatic beta-cells as well as complications of diabetes. This review describes an overview of mechanistic and functional aspects of mitochondrial fission and fusion, and comments on the recent advances connecting mitochondrial dynamics with diabetes and diabetic complications. Antioxid. Redox Signal. 14, 439-457.

引用

页码：439 / 457

页数：19

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