The calpains in aging and aging-related diseases

被引：167

作者：

Nixon, RA ^{[1
]}

机构：

[1] Nathan S Kline Inst Psychiat Res, Ctr Dementia Res, Orangeburg, NY 10962 USA

[2] NYU, Sch Med, Dept Psychiat, New York, NY 10016 USA

[3] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA

来源：

AGEING RESEARCH REVIEWS | 2003年 / 2卷 / 04期

关键词：

calpains; Alzheimer's disease; beta-amyloid;

D O I：

10.1016/S1568-1637(03)00029-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Calpains are a family of calcium-dependent cysteine proteases under complex cellular regulation. By making selective limited proteolytic cleavages, they modulate the activity of enzymes including key signaling molecules, and induce specific cytoskeletal rearrangements, accounting for their roles in cell motility, signal transduction, vesicular trafficking and structural stabilization. Calpain activation has been implicated in various aging phenomena and diseases of late life, including cataract formation, erythrocyte senescence, diabetes mellitus type 2, hypertension, arthritis, and neurodegenerative disorders. The early and pervasive involvement of calpains in Alzheimer's disease potentially influences the development of p-amyloid and tau disturbances and their consequences for neurodegeneration and neuronal cell loss. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：407 / 418

页数：12

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