Modafinil for excessive daytime sleepiness in myotonic dystrophy

被引：59

作者：

Damian, MS ^{[1
]}

Gerlach, A

Schmidt, F

Lehmann, E

Reichmann, H

机构：

[1] Dresden Univ Technol, Carl Gustav Carus Univ Hosp, NICU, Dept Neurol, D-01307 Dresden, Germany

[2] Dresden Univ Technol, Carl Gustav Carus Univ Hosp, Dept Internal Med, D-01307 Dresden, Germany

来源：

NEUROLOGY | 2001年 / 56卷 / 06期

关键词：

D O I：

10.1212/WNL.56.6.794

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors conducted an open-label trial of modafinil for excessive daytime sleepiness in myotonic dystrophy. Eleven patients were evaluated: two were not treated because of obstructive sleep apnea, and nine received 200 to 400 mg modafinil/day for an average of 16.4 weeks. There were no major side effects. Average sleep latency as measured by the Multiple Sleep Latency Test increased from 7.3 to 22.7 minutes (p = 0.00013), and average Epworth Sleepiness Scale score decreased from 13.25 to 7.75 (p = 0.01028). Modafinil shows evidence of effectiveness for excessive daytime somnolence in myotonic dystrophy and should be investigated further.

引用

页码：794 / 796

页数：3

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