Azolidene carbenes derived from biologically relevant molecules. Synthesis and characterization of iridium complexes of imidazolidene ligands based upon the antifungal drugs econazole and miconazole

被引：14

作者：

Davis, JH ^{[1
]}

Lake, CM

Bernard, MA

机构：

[1] Univ S Alabama, Dept Chem, Mobile, AL 36688 USA

[2] Univ Alabama Birmingham, Dept Chem, Birmingham, AL 35294 USA

来源：

INORGANIC CHEMISTRY | 1998年 / 37卷 / 21期

关键词：

D O I：

10.1021/ic9806277

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The azole-based antifungal drugs econazole and miconazole are readily converted into imidazolidene carbenes, which are trapped by coordination to iridium(I). The resulting complexes are the first antifungal drug-metal conjugates incorporating an M-C sigma bond. This demonstration of the capacity of azole-containing bioactive molecules to form carbene ligands may open the door to the investigation of complexes derived from such species for a variety of biological and medicinal purposes.

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页码：5412 / +

页数：3

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