NMR-based screening technologies

被引：56

作者：

Coles, M ^{[1
]}

Heller, M ^{[1
]}

Kessler, H ^{[1
]}

机构：

[1] Tech Univ Munich, Inst Organ Chem & Biochem, D-85747 Garching, Germany

来源：

DRUG DISCOVERY TODAY | 2003年 / 8卷 / 17期

关键词：

D O I：

10.1016/S1359-6446(03)02796-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

NMR-based ligand screening is now an established field in its own right. In recent years, advances in both methodology and hardware have broadened its range of applications and pushed back practical limitations, leading to the growing importance of NMR screening as a tool in industrial drug research. An overview of new screening methods and applications is presented here, and ways in which NMR-screening is being used in cooperation with other screening techniques are discussed.

引用

页码：803 / 810

页数：8

共 69 条

[21] Second-site NMR screening and linker design
Jahnke, W
Flörsheimer, A
Blommers, MJJ
Paris, CG
Heim, J
Nalin, CM
Perez, LB
[J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2003, 3 (01) : 69 - 80
[22] Jahnke W, 2002, ANGEW CHEM INT EDIT, V41, P3420, DOI 10.1002/1521-3773(20020916)41:18<3420::AID-ANIE3420>3.0.CO
[23] 2-E
[24] Spin label enhanced NMR screening
Jahnke, W
Rüdisser, S
Zurini, M
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (13) : 3149 - 3150
[25] NMR tools for biotechnology
Keifer, PA
[J]. CURRENT OPINION IN BIOTECHNOLOGY, 1999, 10 (01) : 34 - 41
[26] Detecting binding affinity to immobilized receptor proteins in compound libraries by HR-MAS STD NMR
Klein, J
Meinecke, R
Mayer, M
Meyer, B
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (22) : 5336 - 5337
[27] Measurement of dipolar couplings in a transducin peptide fragment weakly bound to oriented photo-activated rhodopsin
Koenig, BW
Mitchell, DC
König, S
Grzesiek, S
Litman, BJ
Bax, A
[J]. JOURNAL OF BIOMOLECULAR NMR, 2000, 16 (02) : 121 - 125
[28] The inter-ligand Overhauser effect: A powerful new NMR approach for mapping structural relationships of macromolecular ligands
Li, DW
DeRose, EF
London, RE
[J]. JOURNAL OF BIOMOLECULAR NMR, 1999, 15 (01) : 71 - 76
[29] Logan TM, 1999, MAGN RESON CHEM, V37, P762, DOI 10.1002/(SICI)1097-458X(199910)37:10<762::AID-MRC584>3.3.CO
[30] 2-G

← 1 2 3 4 5 6 7 →