Galectine-I expression in cochleae of C57BL/6 mice during aging

被引：7

作者：

Bartolomé, MV ^{[1
]}

López, LM ^{[1
]}

Gil-Loyzaga, P ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Med, Dept Surg ORL 22, Ctr Cell Culture,CAI,UCM, E-28040 Madrid, Spain

来源：

NEUROREPORT | 2001年 / 12卷 / 14期

关键词：

auditory system; C57BL/6; mouse; cochlea; galectine-1; presbycusis;

D O I：

10.1097/00001756-200110080-00025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Presbycusis is a progressive hearing loss related to the aging process associated with auditory receptor degeneration. Adult animals exhibited galectine-I (GAL-I) expression in epithelial cells of the inner and outer spiral sulci and Hensen cells, which was absent from the sensory and supporting cells. The progressive age-related degeneration of auditory receptor was analyzed using an anti-GAL-I monoclonal antibody on cochleae of C57BL/6 mice (1-24 months old). Mice less than or equal to9 months old showed adult and healthy auditory receptors, with a similar GAL-I expression along the time. Conversely, animals > 1 year old exhibited a sensory degeneration at the cochleae basal coil that progressively reached the middle coil. Older animals (18-24 months old) showed a single layer epithelium that replaced the auditory receptor. The age-related degenerative process of the auditory receptor involves sensory but also supporting cells, which are both substituted by epithelial non-specialized cells. NeuroReport 12:3 107-3110 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：3107 / 3110

页数：4

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