Bastadins, cyclic tetramers of brominated-tyrosine derivatives, selectively inhibit the proliferation of endothelial cells

被引：16

作者：

Aoki, Shunji ^{[1
]}

Cho, Seok-hwan ^{[1
]}

Hiramatsu, Atsushi ^{[1
]}

Kotoku, Naoyuki ^{[1
]}

Kobayashi, Motomasa ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF NATURAL MEDICINES | 2006年 / 60卷 / 03期

关键词：

anti-proliferation; bastadins; endothelial cell; marine sponge;

D O I：

10.1007/s11418-006-0045-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight bastadins, tetramers of brominatedtyrosine derivatives, were isolated from the marine sponge Ianthella basta, and their anti-proliferative activities against endothelial cells were examined. A structure-activity relationship study of these compounds revealed that a macrocyclic structure was crucial, and a bastarane-type skeleton was important for the selective activity of these bastadins against endothelial cells. A conformational analysis of the bastadins was also carried out by molecular mechanics calculation.

引用

页码：231 / 235

页数：5

共 13 条

[1] Bastadin 6, a spongean brominated tyrosine derivative, inhibits tumor angiogenesis by inducing selective apoptosis to endothelial cells [J].

Aoki, Shunji ;

Cho, Seok-hwan ;

Ono, Mayumi ;

Kuwano, Takashi ;

Nakao, Shintaro ;

Kuwano, Michihiko ;

Nakagawa, Shinsaku ;

Gao, Jian-Qing ;

Mayumi, Tadanori ;

Shibuya, Masabumi ;

Kobayashi, Motomasa .

ANTI-CANCER DRUGS, 2006, 17 (03) :269-278

[2] THE BASTADINS REVISITED - NEW CHEMISTRY FROM THE AUSTRALIAN MARINE SPONGE IANTHELLA-BASTA [J].

BUTLER, MS ;

LIM, TK ;

CAPON, RJ ;

HAMMOND, LS .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1991, 44 (02) :287-296

[3] Angiogenesis in cancer and other diseases [J].

Carmeliet, P ;

Jain, RK .

NATURE, 2000, 407 (6801) :249-257

[4] AN INTERNAL COORDINATE MONTE-CARLO METHOD FOR SEARCHING CONFORMATIONAL SPACE [J].

CHANG, G ;

GUIDA, WC ;

STILL, WC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (12) :4379-4386

[5]

FOLKMAN J, 1992, J BIOL CHEM, V267, P10931

[6] Seminars in medicine of the Beth Israel Hospital, Boston - Clinical applications of research on angiogenesis [J].

Folkman, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (26) :1757-1763

[7]

Halgren TA, 1996, J COMPUT CHEM, V17, P490, DOI [10.1002/(SICI)1096-987X(199604)17:5/6<490::AID-JCC1>3.0.CO

[8]

2-P, 10.1002/(SICI)1096-987X(199604)17:5/6<616::AID-JCC5>3.0.CO

[9]

2-X]

[10]

KAZLAUSKAS R, 1981, AUST J CHEM, V34, P765, DOI 10.1071/CH9810765

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