Bastadins, cyclic tetramers of brominated-tyrosine derivatives, selectively inhibit the proliferation of endothelial cells

被引：16

作者：

Aoki, Shunji ^{[1
]}

Cho, Seok-hwan ^{[1
]}

Hiramatsu, Atsushi ^{[1
]}

Kotoku, Naoyuki ^{[1
]}

Kobayashi, Motomasa ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF NATURAL MEDICINES | 2006年 / 60卷 / 03期

关键词：

anti-proliferation; bastadins; endothelial cell; marine sponge;

D O I：

10.1007/s11418-006-0045-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight bastadins, tetramers of brominatedtyrosine derivatives, were isolated from the marine sponge Ianthella basta, and their anti-proliferative activities against endothelial cells were examined. A structure-activity relationship study of these compounds revealed that a macrocyclic structure was crucial, and a bastarane-type skeleton was important for the selective activity of these bastadins against endothelial cells. A conformational analysis of the bastadins was also carried out by molecular mechanics calculation.

引用

页码：231 / 235

页数：5