Palladium-catalyzed sequential alkylation-alkenylation reactions: application towards the synthesis of polyfunctionalized fused aromatic rings

被引：31

作者：

Alberico, D ^{[1
]}

Paquin, JF ^{[1
]}

Lautens, M ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Davenport Labs, Toronto, ON M5S 3H6, Canada

来源：

TETRAHEDRON | 2005年 / 61卷 / 26期

基金：

加拿大自然科学与工程研究理事会;

关键词：

palladium; catalysis; intramolecular heck reaction; norbornene; ortho functionalization; fused aromatic rings; catellani reaction;

D O I：

10.1016/j.tet.2005.03.128

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of polyfunctionalized fused aromatic carbo- and heterocycles from aryl iodides and bromoenoates via a tandem palladium-catalyzed aromatic substitution intramolecular Heck sequence is reported. Using Pd(OAc)(2) and tri-2-furylphosphine (TFP) in the presence of norbornene and Cs2CO3 in CH3CN at 85 degrees C gave a variety of functionalized bi- and tricyclic fused aromatic rings in good yield. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6283 / 6297

页数：15

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