Resveratrol as a new type of DNA-cleaving agent

被引：123

作者：

Fukuhara, K ^{[1
]}

Miyata, N ^{[1
]}

机构：

[1] Natl Inst Hlth Sci, Div Organ Chem, Setagaya Ku, Tokyo 1588501, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(98)00585-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The first demonstration of DNA cleavage by resveratrol '3,5,4'-trihydroxy-trans-stilbene ' is presented. Resveratrol mediated relaxation of pBR322 at micromolar concentrations in the presence of Cu2+. Evidence is provided that resveratrol is capable of binding to DNA, and that the Cu2+-dependent DNA damage is more likely caused by a copper-peroxide complex rather than by a freely diffusible oxygen species. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3187 / 3192

页数：6

共 24 条

[1] 5-ALKYLRESORCINOLS FROM HAKEA-AMPLEXICAULIS THAT CLEAVE DNA [J].

BARR, JR ;

MURTY, VS ;

YAMAGUCHI, K ;

SINGH, S ;

SMITH, DH ;

HECHT, SM .

CHEMICAL RESEARCH IN TOXICOLOGY, 1988, 1 (04) :204-207

[2] Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins [J].

Belguendouz, L ;

Fremont, L ;

Linard, A .

BIOCHEMICAL PHARMACOLOGY, 1997, 53 (09) :1347-1355

[3] INHIBITION OF HUMAN LDL OXIDATION BY RESVERATROL [J].

FRANKEL, EN ;

WATERHOUSE, AL ;

KINSELLA, JE .

LANCET, 1993, 341 (8852) :1103-1104

[4]

FUKUHARA K, UNPUB

[5] MECHANISMS OF THE REACTIONS OF SOME COPPER-COMPLEXES IN THE PRESENCE OF DNA WITH O2-, H2O2, AND MOLECULAR-OXYGEN [J].

GOLDSTEIN, S ;

CZAPSKI, G .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (09) :2244-2250

[6] NATURAL-PRODUCTS THAT CLEAVE DNA [J].

HECHT, SM .

PURE AND APPLIED CHEMISTRY, 1989, 61 (03) :577-580

[7] CLEAVAGE OF DOUBLE HELICAL DNA BY (METHIDIUMPROPYL-EDTA)IRON(II) [J].

HERTZBERG, RP ;

DERVAN, PB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (01) :313-315

[8]

Hiraku Y, 1996, CANCER RES, V56, P5172

[9] STRAND SCISSION IN DNA INDUCED BY L-DOPA IN THE PRESENCE OF CU(II) [J].

HUSAIN, S ;

HADI, SM .

FEBS LETTERS, 1995, 364 (01) :75-78

[10]

JAN M, 1997, SCIENCE, V275, P218

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