Calcium in tumour metastasis: new roles for known actors

被引：499

作者：

Prevarskaya, Natalia ^{[1
,2
]}

Skryma, Roman ^{[1
,2
]}

Shuba, Yaroslav ^{[3
,4
]}

机构：

[1] INSERM, U1003, Lab Physiol Cellulaire, Equipe Labellisee Ligue Canc, F-59650 Villeneuve Dascq, France

[2] Univ Lille 1, F-59650 Villeneuve Dascq, France

[3] NASU, Bogomoletz Inst Physiol, UA-01024 Kiev 24, Ukraine

[4] NASU, Int Ctr Mol Physiol, UA-01024 Kiev 24, Ukraine

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 08期

关键词：

FOCAL ADHESION KINASE; HUMAN PROSTATE-CANCER; CYCLIC ADP-RIBOSE; CELL-MIGRATION; MATRIX METALLOPROTEINASES; CHANNEL EXPRESSION; CA2+ CHANNELS; TRP CHANNELS; HUMAN GLIOMA; PROTEIN;

D O I：

10.1038/nrc3105

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In most cases, metastasis, not the primary tumour per se, is the main cause of mortality in cancer patients. In order to effectively escape the tumour, enter the circulation and establish secondary growth in distant organs cancer cells must develop an enhanced propensity to migrate. The ubiquitous second messenger Ca2+ is a crucial regulator of cell migration. Recently, a number of known molecular players in cellular Ca2+ homeostasis, including calcium release-activated calcium channel protein 1 (ORAI1), stromal interaction molecule 1 (STIM1) and transient receptor potential (TRP) channels, have been implicated in tumour cell migration and the metastatic cell phenotype. We discuss how these developments have increased our understanding of the Ca2+ dependence of pro-metastatic behaviours.

引用

页码：609 / 618

页数：10

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