Programmed necrosis: backup to and competitor with apoptosis in the immune system

被引：304

作者：

Han, Jiahuai ^{[1
]}

Zhong, Chuan-Qi ^{[1
]}

Zhang, Duan-Wu ^{[1
]}

机构：

[1] Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen, Peoples R China

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 12期

基金：

中国国家自然科学基金;

关键词：

INDUCED CELL-DEATH; KAPPA-B ACTIVATION; KINASE RIP; CASPASE-8; PROTEIN; INHIBITION; FAS; NECROPTOSIS; MACROPHAGES; MECHANISMS;

D O I：

10.1038/ni.2159

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Programmed cell death is essential for the development and maintenance of the immune system and its responses to exogenous and endogenous stimuli. Studies have demonstrated that in addition to caspase-dependent apoptosis, necrosis dependent on the kinases RIP1 and RIP3 (also called necroptosis) is a major programmed cell-death pathway in development and immunity. These two programmed cell-death pathways may suppress each other, and necroptosis also serves as an alternative when caspase-dependent apoptosis is inhibited or absent. Here we summarize recent advancements that have identified the molecular mechanisms that underlie necroptosis and explore the mechanisms that regulate the interplay between apoptosis and necroptosis.

引用

页码：1143 / 1149

页数：7

共 99 条

[1] Proteolytic mechanisms in necrotic cell death and neurodegeneration [J].

Artal-Sanz, M ;

Tavernarakis, N .

FEBS LETTERS, 2005, 579 (15) :3287-3296

[2] The fate of epithelial cells in the human large intestine [J].

Barkla, DH ;

Gibson, PR .

PATHOLOGY, 1999, 31 (03) :230-238

[3] Cutting edge: Innate Immunity conferred by B cells is regulated by caspase-8 [J].

Beisner, DR ;

Ch'en, IL ;

Kolla, RV ;

Hoffmann, A ;

Hedrick, SM .

JOURNAL OF IMMUNOLOGY, 2005, 175 (06) :3469-3473

[4] The requirements for fas-associated death domain signaling in mature T cell activation and survival [J].

Beisner, DR ;

Chu, IH ;

Arechiga, AF ;

Hedrick, SM ;

Walsh, CM .

JOURNAL OF IMMUNOLOGY, 2003, 171 (01) :247-256

[5] FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells [J].

Bell, Bryan D. ;

Leverrier, Sabrina ;

Weist, Brian M. ;

Newton, Ryan H. ;

Arechiga, Adrian F. ;

Luhrs, Keith A. ;

Morrissette, Naomi S. ;

Walsh, Craig M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (43) :16677-16682

[6] Role of caspase-8 in hepatocyte response to infection and injury in mice [J].

Ben Moshe, Tehila ;

Barash, Hila ;

Kang, Tae-Bong ;

Kim, Jin-Chul ;

Kovalenko, Andrew ;

Gross, Eitan ;

Schuchmann, Marcus ;

Abramovitch, Rinat ;

Galun, Eithan ;

Wallach, David .

HEPATOLOGY, 2007, 45 (04) :1014-1024

[7] cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination [J].

Bertrand, Mathieu J. M. ;

Milutinovic, Snezana ;

Dickson, Kathleen M. ;

Ho, Wai Chi ;

Boudreault, Alain ;

Durkin, Jon ;

Gillard, John W. ;

Jaquith, James B. ;

Morris, Stephen J. ;

Barker, Philip A. .

MOLECULAR CELL, 2008, 30 (06) :689-700

[8] Lysosomal membrane permeabilization in cell death [J].

Boya, P. ;

Kroemer, G. .

ONCOGENE, 2008, 27 (50) :6434-6451

[9] Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production [J].

Brouckaert, G ;

Kalai, M ;

Krysko, DV ;

Saelens, X ;

Vercammen, D ;

Ndlovu, M ;

Haegeman, G ;

D'Herde, K ;

Vandenabeele, P .

MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (03) :1089-1100

[10] Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury [J].

Cao, Guodong ;

Xing, Juan ;

Xiao, Xiao ;

Liou, Anthony K. F. ;

Gao, Yanqin ;

Yin, Xiao-Ming ;

Clark, Robert S. B. ;

Graham, Steven H. ;

Chen, Jun .

JOURNAL OF NEUROSCIENCE, 2007, 27 (35) :9278-9293

← 1 2 3 4 5 6 7 8 9 10 →