Programmed necrosis: backup to and competitor with apoptosis in the immune system

被引：304

作者：

Han, Jiahuai ^{[1
]}

Zhong, Chuan-Qi ^{[1
]}

Zhang, Duan-Wu ^{[1
]}

机构：

[1] Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen, Peoples R China

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 12期

基金：

中国国家自然科学基金;

关键词：

INDUCED CELL-DEATH; KAPPA-B ACTIVATION; KINASE RIP; CASPASE-8; PROTEIN; INHIBITION; FAS; NECROPTOSIS; MACROPHAGES; MECHANISMS;

D O I：

10.1038/ni.2159

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Programmed cell death is essential for the development and maintenance of the immune system and its responses to exogenous and endogenous stimuli. Studies have demonstrated that in addition to caspase-dependent apoptosis, necrosis dependent on the kinases RIP1 and RIP3 (also called necroptosis) is a major programmed cell-death pathway in development and immunity. These two programmed cell-death pathways may suppress each other, and necroptosis also serves as an alternative when caspase-dependent apoptosis is inhibited or absent. Here we summarize recent advancements that have identified the molecular mechanisms that underlie necroptosis and explore the mechanisms that regulate the interplay between apoptosis and necroptosis.

引用

页码：1143 / 1149

页数：7

共 99 条

[31] Rapid, noninflammatory and PS-dependent phagocytic clearance of necrotic cells [J].

Hirt, UA ;

Leist, M .

CELL DEATH AND DIFFERENTIATION, 2003, 10 (10) :1156-1164

[32] Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway [J].

Hitomi, Junichi ;

Christofferson, Dana E. ;

Ng, Aylwin ;

Yao, Jianhua ;

Degterev, Alexei ;

Xavier, Ramnik J. ;

Yuan, Junying .

CELL, 2008, 135 (07) :1311-1323

[33] Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule [J].

Holler, N ;

Zaru, R ;

Micheau, O ;

Thome, M ;

Attinger, A ;

Valitutti, S ;

Bodmer, JL ;

Schneider, P ;

Seed, B ;

Tschopp, J .

NATURE IMMUNOLOGY, 2000, 1 (06) :489-495

[34] The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells [J].

Imtiyaz, Hongxia Z. ;

Rosenberg, Stephen ;

Zhang, Yuhang ;

Rahman, Ziaur S. M. ;

Hou, Ying-Ju ;

Manser, Tim ;

Zhang, Jianke .

JOURNAL OF IMMUNOLOGY, 2006, 176 (11) :6852-6861

[35] Requirement of FADD, NEMO, and BAX/BAK for Aberrant Mitochondrial Function in Tumor Necrosis Factor Alpha-Induced Necrosis [J].

Irrinki, Krishna M. ;

Mallilankaraman, Karthik ;

Thapa, Roshan J. ;

Chandramoorthy, Harish C. ;

Smith, Frank J. ;

Jog, Neelakshi R. ;

Gandhirajan, Rajesh Kumar ;

Kelsen, Steven G. ;

Houser, Steven R. ;

May, Michael J. ;

Balachandran, Siddharth ;

Madesh, Muniswamy .

MOLECULAR AND CELLULAR BIOLOGY, 2011, 31 (18) :3745-3758

[36] Receptor-Interacting Protein Homotypic Interaction Motif-Dependent Control of NF-κB Activation via the DNA-Dependent Activator of IFN Regulatory Factors [J].

Kaiser, William J. ;

Upton, Jason W. ;

Mocarski, Edward S. .

JOURNAL OF IMMUNOLOGY, 2008, 181 (09) :6427-6434

[37] RIP3 mediates the embryonic lethality of caspase-8-deficient mice [J].

Kaiser, William J. ;

Upton, Jason W. ;

Long, Alyssa B. ;

Livingston-Rosanoff, Devon ;

Daley-Bauer, Lisa P. ;

Hakem, Razqallah ;

Caspary, Tamara ;

Mocarski, Edward S. .

NATURE, 2011, 471 (7338) :368-+

[38] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif [J].

Kaiser, WJ ;

Offermann, MK .

JOURNAL OF IMMUNOLOGY, 2005, 174 (08) :4942-4952

[39] Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA [J].

Kalai, M ;

Van Loo, G ;

Vanden Berghe, T ;

Meeus, A ;

Burm, W ;

Saelens, X ;

Vandenabeele, P .

CELL DEATH AND DIFFERENTIATION, 2002, 9 (09) :981-994

[40] Caspase-8 serves both apoptotic and nonapoptotic roles [J].

Kang, TB ;

Ben-Moshe, T ;

Varfolomeev, EE ;

Pewzner-Jung, Y ;

Yogev, N ;

Jurewicz, A ;

Waisman, A ;

Brenner, O ;

Haffner, R ;

Gustafsson, E ;

Ramakrishnan, P ;

Lapidot, T ;

Wallach, D .

JOURNAL OF IMMUNOLOGY, 2004, 173 (05) :2976-2984

← 1 2 3 4 5 6 7 8 9 10 →