Calcium crystal effects on the cells of the joint: implications for pathogenesis of disease

被引:25
作者
Cheung, HS [1 ]
机构
[1] Univ Miami, Sch Med, Dept Med, Div Rheumatol & Immunol D26, Miami, FL 33101 USA
[2] Miami Vet Affairs Med Ctr, Res Serv, Miami, FL USA
[3] Miami Vet Affairs Med Ctr, Ctr Geriatr Res Educ & Clin, Miami, FL USA
关键词
D O I
10.1097/00002281-200005000-00012
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In the past three years, there has been considerable progress in delineating the mechanism of calcium-containing crystal-induced cell activation: (1) the identification of Ca2+ influx and p42/44 mitogen-activated protein kinase activation as the signal transduction pathways; (2) induction of nuclear transcription factors of cyclic adenosine monophosphate (cAMP) response element binding protein, activator protein-1, and nuclear factor kappa B; (3) the differential role of crystal endocytosis and dissolution in crystal-induced metalloproteinase synthesis and mitogenesis; (4) crystal upregulation of matrix metalloproteinases, including MMP-13 but downregulation of tissue inhibitor of metalloproteinase-1 and -2, thus magnifying the degenerative effect of crystals. Phosphocitrate, a specific inhibitor of biologic effect of calcium crystals, reverses the degenerative effects of crystals, Curr Opin Rheumatol 2000, 12:223-227 (C) 2000 Lippincott Williams & Wilkins, Inc.
引用
收藏
页码:223 / 227
页数:5
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