Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa

被引：64

作者：

Nakano, M

Deguchi, T

Kawamura, T

Yasuda, M

Kimura, M

Okano, Y

Kawada, Y

机构：

[1] GIFU UNIV,SCH MED,DEPT UROL,GIFU 500,JAPAN

[2] GIFU UNIV,SCH MED,DEPT MOL PATHOBIOCHEM,GIFU 500,JAPAN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 10期

关键词：

D O I：

10.1128/AAC.41.10.2289

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We determined partial sequences of the gyrA and parC genes of the fluoroquinolone-susceptible strain ATCC 27853 and 22 clinical isolates of Pseudomonas aeruginosa. While a single amino acid change in GyrA with or without a change in ParC was found in 14 isolates with decreased susceptibility to fluoroquinolones, 3 higher-level fluoroquinolone-resistant isolates had a double amino acid change in GyrA and a single amino acid change in ParC.

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页码：2289 / 2291

页数：3

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共 16 条

[1] Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV [J].

Breines, DM ;

Ouabdesselam, S ;

Ng, EY ;

Tankovic, J ;

Shah, S ;

Soussy, CJ ;

Hooper, DC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (01) :175-179

[2] ROLE OF MUTATIONS IN DNA GYRASE GENES IN CIPROFLOXACIN RESISTANCE OF PSEUDOMONAS-AERUGINOSA SUSCEPTIBLE OR RESISTANT TO IMIPENEM [J].

CAMBAU, E ;

PERANI, E ;

DIB, C ;

PETINON, C ;

TRIAS, J ;

JARLIER, V .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (10) :2248-2252

[3] NEW NORFLOXACIN RESISTANCE GENE IN PSEUDOMONAS-AERUGINOSA PAO [J].

FUKUDA, H ;

HOSAKA, M ;

HIRAI, K ;

IYOBE, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (09) :1757-1761

[4]

*JAP SOC CHEM, 1981, CHEMOTHERAPY, V29, P76

[5] NEW TOPOISOMERASE ESSENTIAL FOR CHROMOSOME SEGREGATION IN ESCHERICHIA-COLI [J].

KATO, J ;

NISHIMURA, Y ;

IMAMURA, R ;

NIKI, H ;

HIRAGA, S ;

SUZUKI, H .

CELL, 1990, 63 (02) :393-404

[6] COMPARISON OF ARBITRARILY PRIMED PCR AND MACRORESTRICTION (PULSED-FIELD GEL-ELECTROPHORESIS) TYPING OF PSEUDOMONAS-AERUGINOSA STRAINS FROM CYSTIC-FIBROSIS PATIENTS [J].

KERSULYTE, D ;

STRUELENS, MJ ;

DEPLANO, A ;

BERG, DE .

JOURNAL OF CLINICAL MICROBIOLOGY, 1995, 33 (08) :2216-2219

[7] CLONING AND NUCLEOTIDE-SEQUENCE OF PSEUDOMONAS-AERUGINOSA DNA GYRASE GYRA GENE FROM STRAIN PAO1 AND QUINOLONE-RESISTANT CLINICAL ISOLATES [J].

KUREISHI, A ;

DIVER, JM ;

BECKTHOLD, B ;

SCHOLLAARDT, T ;

BRYAN, LE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (09) :1944-1952

[8] OFLOXACIN-RESISTANT PSEUDOMONAS-AERUGINOSA MUTANTS WITH ELEVATED DRUG EXTRUSION ACROSS THE INNER MEMBRANE [J].

LEI, Y ;

SATO, K ;

NAKAE, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 178 (03) :1043-1048

[9] ROLE OF MEXA-MEXB-OPRM IN ANTIBIOTIC EFFLUX IN PSEUDOMONAS-AERUGINOSA [J].

LI, XZ ;

NIKAIDO, H ;

POOLE, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (09) :1948-1953

[10] OUTER-MEMBRANE PROTEINS RESPONSIBLE FOR MULTIPLE-DRUG RESISTANCE IN PSEUDOMONAS-AERUGINOSA [J].

MASUDA, N ;

SAKAGAWA, E ;

OHYA, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (03) :645-649