Carbon Dots for Optical Imaging in Vivo

被引：1319

作者：

Yang, Sheng-Tao ^{[1
,2
,3
]}

Cao, Li ^{[2
,3
]}

Luo, Pengju G. ^{[2
,3
]}

Lu, Fushen ^{[2
,3
]}

Wang, Xin ^{[2
,3
]}

Wang, Haifang ^{[1
,4
]}

Meziani, Mohammed J. ^{[2
,3
]}

Liu, Yuanfang ^{[1
,4
]}

Qi, Gang ^{[2
,3
]}

Sun, Ya-Ping ^{[2
,3
]}

机构：

[1] Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China

[2] Clemson Univ, Dept Chem, Clemson, SC 29634 USA

[3] Clemson Univ, Lab Emerging Mat & Technol, Clemson, SC 29634 USA

[4] Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 32期

关键词：

QUANTUM DOTS; NANOPARTICLES; NANOCRYSTALS; TOXICITY;

D O I：

10.1021/ja904843x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It was found and recently reported that small carbon nanoparticles can be surface-passivated by organic or biomolecules to become strongly fluorescent. These fluorescent carbon nanoparticles, dubbed "carbon dots", can be successfully used for in vitro cell imaging with both one- and two-photon excitations, as already demonstrated in the literature. Here we report the first study using carbon dots for optical imaging in live mice. The results suggest that the carbon dots remain strongly fluorescent in vivo, which, coupled with their biocompatibility and nontoxic characteristics, might offer great potential for imaging and related biomedical applications.

引用

页码：11308 / +

页数：4

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