Synthesis of tritium labelled 2-C-methyl-D-erythritol, a useful substrate for the elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis

被引：12

作者：

Hoeffler, JF ^{[1
]}

Grosdemange-Billiard, C ^{[1
]}

Rohmer, M ^{[1
]}

机构：

[1] Univ Louis Pasteur Strasbourg 1, CNRS, Inst Le Bel, F-67070 Strasbourg, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 25期

关键词：

biosynthesis; isoprenoids; 2-C-methyl-D-erythritol;

D O I：

10.1016/S0040-4039(00)00726-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Free 2-C-methyl-D-erythritol is utilised for isoprenoid biosynthesis by Escherichia coli mutants lacking the two first enzymes of the methylerythritol phosphate pathway, the deoxyxylulose phosphate synthase and isomero-reductase. For feeding experiments, this tetrol was synthesised with an overall 43% yield from readily available 1,2-O-isopropylidene-alpha-D-xylofuranose, including the possibility of tritium labelling. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4885 / 4889

页数：5

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