Peripheral Cytokines and Chemokines in Alzheimer's Disease

被引：121

作者：

Lee, Kang Soo ^{[2
,3
]}

Chung, Ji Hyung ^{[4
,5
]}

Choi, Tae Kyou ^{[2
]}

Suh, Shin Young ^{[2
]}

Oh, Byoung Hoon ^{[3
]}

Hong, Chang Hyung ^{[1
,6
]}

机构：

[1] Ajou Univ, Sch Med, Dept Psychiat, Suwon 443749, South Korea

[2] CHA Univ, Bundang Cha Med Ctr, Dept Psychiat, Songnam, South Korea

[3] Yonsei Univ, Grad Sch, Dept Med, Seoul 120749, South Korea

[4] Yonsei Integrat Res Inst Cerebral & Cardiovasc Di, Seoul, South Korea

[5] Yonsei Univ Hlth Syst, Seoul, South Korea

[6] Ajou Univ Hosp, Memory Impairment Ctr, Suwon, South Korea

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2009年 / 28卷 / 04期

关键词：

Alzheimer's disease; Inflammation; Cytokines; Chemokines; Biomarkers; NECROSIS-FACTOR-ALPHA; MILD COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID; INFLAMMATORY MARKERS; SERUM INTERLEUKIN-6; VASCULAR DEMENTIA; MULTIINFARCT DEMENTIA; INTERFERON-GAMMA; TNF-ALPHA; PLASMA;

D O I：

10.1159/000245156

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

A chronic inflammatory process has been implicated in the neuropathology of Alzheimer's disease (AD). The present review focuses on the current knowledge of circulating serum and plasma biomarkers of AD that are linked to inflammatory reactions. There is abundant evidence that inflammatory mechanisms within the central nervous system contribute to cognitive impairment via cytokine-mediated interactions between neurons and glial cells. Interleukins 1, 4, 6, 10, 12, 16, and 18, tumour necrosis factor, and several chemokines have been suggested as biomarkers of AD. Nonetheless, data on circulating cytokine levels are somewhat inconsistent with regard to peripheral cytokine dysregulation in AD. In summary, definite statements concerning differences in inflammatory biomarkers between controls and AD patients will require the use of sensitive multiplex assays in large patient groups in conjunction with measures of disease severity. Copyright (c) 2009 S. Karger AG, Basel

引用

页码：281 / 287

页数：7

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