Serum interleukin-6 and interleukin-6 soluble receptor in Alzheimer's disease

被引：70

作者：

Angelis, P

Scharf, S

Mander, A

Vajda, F

Christophidis, N

机构：

[1] St Vincents Hosp, Dept Clin Pharmacol, Fitzroy, Vic 3065, Australia

[2] Grace McKellar Ctr, N Geelong, Vic 3215, Australia

[3] St Vincents Hosp, Australian Ctr Clin Neuropharmacol, Melbourne, Vic, Australia

来源：

NEUROSCIENCE LETTERS | 1998年 / 244卷 / 02期

基金：

英国医学研究理事会;

关键词：

interleukin-6; interleukin-6 soluble receptor; Alzheimer's disease; serum;

D O I：

10.1016/S0304-3940(98)00136-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Serum levels of interleukin-6 (IL-6) and interleukin-6 soluble receptor (IL-6sR) were measured in 41 patients (23 female and 18 male, mean age 72.5 years) with Alzheimer's disease (AD) and in 32 controls (14 women and 18 men, mean age 69.2 years) using enzyme-linked immunosorbent assays (ELISA). Proportions of individuals with detectable serum IL-6 concentrations did not differ significantly between patients and controls. There was however, a significant decrease in IL-6sR levels in Alzheimer's patients when compared with controls. Our results suggest that there is a dysregulation of IL-6 and its soluble receptor in AD. (C) 1998 Elsevier Science Ireland Ltd.

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收藏

页码：106 / 108

页数：3

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