Plant seeds as bioreactors for recombinant protein production

被引：109

作者：

Lau, On Sun ^{[2
]}

Sun, Samuel S. M. ^{[1
,3
]}

机构：

[1] Chinese Univ Hong Kong, Dept Biol, Shatin, Hong Kong, Peoples R China

[2] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

[3] Chinese Univ Hong Kong, State China Key Lab Agrobiotechnol, Hong Kong, Hong Kong, Peoples R China

来源：

BIOTECHNOLOGY ADVANCES | 2009年 / 27卷 / 06期

关键词：

Seed bioreactor; Molecular farming; Plant-made pharmaceuticals; Recombinant proteins; Transgenic plants; Protein targeting; Maize; Rice; TRANSGENIC RICE SEEDS; FRAGMENT SCFV ANTIBODY; HIGH-LEVEL EXPRESSION; HEPATITIS-B-VIRUS; ENDOPLASMIC-RETICULUM; PHARMACEUTICAL PROTEINS; COMMERCIAL PRODUCTION; EDIBLE VACCINE; LT-B; MONOCLONAL-ANTIBODY;

D O I：

10.1016/j.biotechadv.2009.05.005

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Plants are attractive expression systems for the economic production of recombinant proteins. Among the different plant-based systems. plant seed is the leading platform and holds several advantages such as high protein yields and stable storage of target proteins Significant advances in using seeds as bioreactors have occurred in the past decade. which include the first commercialized plant-derived recombinant protein Here we review the current progress on seeds as bioreactors. with focus on the different food crops as production platforms and comprehensive strategies in optimizing recombinant protein production in seeds (C) 2009 Elsevier Inc All rights reserved

引用

页码：1015 / 1022

页数：8

共 122 条

[31] Protein storage bodies and vacuoles [J].

Herman, EM ;

Larkins, BA .

PLANT CELL, 1999, 11 (04) :601-613

[32] The ubiquitin system [J].

Hershko, A ;

Ciechanover, A .

ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 :425-479

[33] PRODUCTION OF ANTIBODIES IN TRANSGENIC PLANTS [J].

HIATT, A ;

CAFFERKEY, R ;

BOWDISH, K .

NATURE, 1989, 342 (6245) :76-78

[34] Use of ubiquitin fusions to augment protein expression in transgenic plants [J].

Hondred, D ;

Walker, JM ;

Mathews, DE ;

Vierstra, RD .

PLANT PHYSIOLOGY, 1999, 119 (02) :713-723

[35] Commercial production of avidin from transgenic maize: characterization of transformant, production, processing, extraction and purification [J].

Hood, EE ;

Witcher, DR ;

Maddock, S ;

Meyer, T ;

Baszczynski, C ;

Bailey, M ;

Flynn, P ;

Marshall, L ;

Bond, D ;

Kulisek, E ;

Kusnadi, A ;

Evangelista, R ;

Nikolov, Z ;

Wooge, C ;

Mehigh, RJ ;

Hernan, R ;

Kappel, WK ;

Ritland, D ;

Li, CP ;

Howard, JA .

MOLECULAR BREEDING, 1997, 3 (04) :291-306

[36] Criteria for high-level expression of a fungal laccase gene in transgenic maize [J].

Hood, EE ;

Bailey, MR ;

Beifuss, K ;

Magallanes-Lundback, M ;

Horn, ME ;

Callaway, E ;

Drees, C ;

Delaney, DE ;

Clough, R ;

Howard, JA .

PLANT BIOTECHNOLOGY JOURNAL, 2003, 1 (02) :129-140

[37] From green plants to industrial enzymes [J].

Hood, EE .

ENZYME AND MICROBIAL TECHNOLOGY, 2002, 30 (03) :279-283

[38] Plant molecular farming: systems and products [J].

Horn, ME ;

Woodard, SL ;

Howard, JA .

PLANT CELL REPORTS, 2004, 22 (10) :711-720

[39] The production of recombinant proteins in transgenic barley grains [J].

Horvath, H ;

Huang, JT ;

Wong, O ;

Kohl, E ;

Okita, T ;

Kannangara, CG ;

von Wettstein, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (04) :1914-1919

[40] Analysis of the rice endosperm-specific globulin promoter in transformed rice cells [J].

Hwang, YS ;

Yang, D ;

McCullar, C ;

Wu, L ;

Chen, L ;

Pham, P ;

Nandi, S ;

Huang, N .

PLANT CELL REPORTS, 2002, 20 (09) :842-847

← 1 2 3 4 5 6 7 8 9 10 →