A rapid and simple cleanup procedure for metathesis reactions

被引：114

作者：

Galan, Brandon R. ^{[1
]}

Kalbarczyk, Kyle P. ^{[1
]}

Szczepankiewicz, Steven ^{[1
]}

Keister, Jerome B. ^{[1
]}

Diver, Steven T. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Amherst, NY 14260 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 07期

关键词：

D O I：

10.1021/ol0631399

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

A new method for easy removal of ruthenium from metathesis reactions by using a polar isocyanide is reported. This protocol removed most ruthenium byproducts from a variety of synthetically useful metatheses. Moreover, the isocyanide-promoted carbene insertion results in rapid destruction of carbene reactivity, demonstrated in the commonly used first- and second-generation Grubbs' carbenes.

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页码：1203 / 1206

页数：4

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