Myocardial water handling and the role of aquaporins

被引：48

作者：

Egan, Jonathan R.

Butler, Tanya L.

Au, Carol G.

Tan, Yee Mun

North, Kathryn N.

Winlaw, David S. ^{[1
]}

机构：

[1] Univ Sydney, Discipline Pediat & Child Hlth, Fac Med, Sydney, NSW 2006, Australia

[2] Childrens Hosp Westmead, Kids Heart Res, Sydney, NSW, Australia

[3] Childrens Hosp Westmead, Neurogenet Res Unit, Sydney, NSW, Australia

[4] Childrens Hosp Westmead, Inst Neuromuscular Res, Sydney, NSW, Australia

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2006年 / 1758卷 / 08期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

membrane permeability; myocardium; cardiopulmonary bypass; myocardial edema; aquaporin; dystrophin associated complex;

D O I：

10.1016/j.bbamem.2006.05.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiac surgery is performed in approximately 770,000 adults and 30,000 children in the United States of America annually. In this review we outline the mechanistic links between post-operative myocardial stunning and the development of myocardial edema. These interrelated processes cause a decline in myocardial performance that account for significant morbidity and mortality after cardiac surgery. Factors leading to myocardial edema include hemodilution, ischemia and reperfusion as well as osmotic gradients arising from pathological change. Several members of the aquaporin family of water transport proteins have been described in the myocardium although their role in the pathogenesis and resolution of cardiac edema is not established. This review examines evidence for the involvement of aquaporins in myocardial water handling during normal and pathological conditions. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：1043 / 1052

页数：10

共 114 条

[1] Aquaporin water channels (Nobel lecture) [J].