Antibacterial discovery and development - the failure of success?

被引：192

作者：

Fernandes, Prabhavathi ^{[1
]}

机构：

[1] Cempra Pharmaceut Inc, Morrisville, NC 27560 USA

来源：

NATURE BIOTECHNOLOGY | 2006年 / 24卷 / 12期

关键词：

D O I：

10.1038/nbt1206-1497

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A combination of approaches and compounds - many of which failed to yield immediate results in the past - will ultimately prove invaluable to the drug industry in the ongoing battle against infectious disease. © 2006 Nature Publishing Group.

引用

页码：1497 / 1503

页数：7

共 79 条

[71] Discovery and development of sorafenib: a multikinase inhibitor for treating cancer [J].

Wilhelm, Scott ;

Carter, Christopher ;

Lynch, Mark ;

Lowinger, Timothy ;

Dumas, Jacques ;

Smith, Roger A. ;

Schwartz, Brian ;

Simantov, Ronit ;

Kelley, Susan .

NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (10) :835-844

[72] Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells [J].

Woods, A ;

Dickerson, K ;

Heath, R ;

Hong, SP ;

Momcilovic, M ;

Johnstone, SR ;

Carlson, M ;

Carling, D .

CELL METABOLISM, 2005, 2 (01) :21-33

[73]

XIONG YQ, 2003, DRUG TODAY, V36, P631

[74] An array of Escherichia coli clones over-expressing essential proteins:: A new strategy of identifying cellular targets of potent antibacterial compounds [J].

Xu, H. Howard ;

Real, Lilian ;

Bailey, Melissa Wu .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 349 (04) :1250-1257

[75] Biochemical characterization of the interactions of the novel pleuromutilin derivative retapamulin with bacterial ribosomes [J].

Yan, Kang ;

Madden, Lenore ;

Choudhry, Anthony E. ;

Voigt, Christine S. ;

Copeland, Robert A. ;

Gontarek, Richard R. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (11) :3875-3881

[76] The evolution of peptide deformylase as a target: Contribution of biochemistry, genetics and genomics [J].

Yuan, ZY ;

White, RJ .

BIOCHEMICAL PHARMACOLOGY, 2006, 71 (07) :1042-1047

[77] Structure-guided discovery of novel aminoglycoside mimetics as antibacterial translation inhibitors [J].

Zhou, YF ;

Gregor, VE ;

Sun, ZX ;

Ayida, BK ;

Winters, GC ;

Murphy, D ;

Simonsen, KB ;

Vourloumis, D ;

Fish, S ;

Froelich, JM ;

Wall, D ;

Hermann, T .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (12) :4942-4949

[78] Rational design of macrolides by virtual screening of combinatorial libraries generated through in silico manipulation of polyketide synthases [J].

Zotchev, SB ;

Stepanchikova, AV ;

Sergeyko, AP ;

Sobolev, BN ;

Filimonov, DA ;

Poroikov, VV .

JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (06) :2077-2087

[79]

1995, FDC REP PRESCRIPR PH, V57, P6

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