Bacterial sensing of and resistance to gold salts

被引：106

作者：

Checa, Susana K. ^{[1
]}

Espariz, Martin ^{[1
]}

Perez Audero, Maria E. ^{[1
]}

Botta, Pablo E. ^{[1
]}

Spinelli, Silvana V. ^{[1
]}

Soncini, Fernando C. ^{[1
]}

机构：

[1] Univ Nacl Rosario, Inst Biol Mol & Celular Rosario, Consejo Nacl Invest Cient & Tecn, Dept Microbiol,Fac Ciencias Bioquim & Farmaceut, RA-2002 Rosario, Argentina

来源：

MOLECULAR MICROBIOLOGY | 2007年 / 63卷 / 05期

关键词：

D O I：

10.1111/j.1365-2958.2007.05590.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The MerR family is a group of bacterial transcriptional regulators that respond to different environmental stimuli, such as heavy metals, oxidative stress or antibiotics. Here we characterize a new member of this family that is highly selective for Au ions. We show that this Salmonella regulator, named GolS, directly controls the expression of at least two transcriptional units specifically required for Au resistance. By chromosomal mutagenesis, we demonstrated that Au-selectivity is accomplished by a metal-binding motif in GolS. Among the monovalent metal-ion sensing MerR regulators GolS clusters in a branch distant from enterobacterial CueR orthologues. We propose that GolS and its homologues evolved to cope with toxic concentration of Au ion, allowing microorganisms to withstand contaminated environments.

引用

页码：1307 / 1318

页数：12

共 53 条

[1] Phosphorylated PmrA interacts with the promoter region of ugd in Salmonella enterica serovar Typhimurium [J].