Syndecan recyling is controlled by syntenin-PIP2 interaction and AM

被引：180

作者：

Zimmermann, P ^{[1
]}

Zhang, Z

Degeest, G

Mortier, E

Leenaerts, I

Coomans, C

Schulz, J

N'Kuli, F

Courtoy, PJ

David, G

机构：

[1] Katholieke Univ Leuven, Dept Human Genet, Lab Glycobiol & Dev Genet, B-3000 Louvain, Belgium

[2] Flanders Interuniv Inst Biotechnol, B-3000 Louvain, Belgium

[3] Catholic Univ Louvain, Christian de Duve Inst Cellular Pathol, Cell Unit, B-1200 Brussels, Belgium

来源：

DEVELOPMENTAL CELL | 2005年 / 9卷 / 03期

关键词：

D O I：

10.1016/j.devcel.2005.07.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Syndecans are heparan sulfate proteoglycans that modulate the activity of several growth factors and cell adhesion molecules. PDZ domains in the adaptor protein syntenin interact with syndecans and with the phosphoinositide PIP2, which is involved in the regulation of the actin cytoskeleton and membrane trafficking. Here, we show that the syntenin PDZ domain-PIP2 interaction controls Arf6-mediated syndecan recycling through endosomal compartments. FGF receptor accompanies syndecan along the syntenin-mediated recycling pathway, in a heparan sulfate- and FGF-dependent manner. Syndecans that cannot recycle via this pathway become trapped intracellularly and inhibit cell spreading. This syntenin-mediated syndecan recycling pathway may regulate the surface availability of a number of cell adhesion and signaling molecules.

引用

页码：377 / 388

页数：12

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