Animal models of preeclampsia

被引:56
作者
Podjarny, E [1 ]
Baylis, C
Losonczy, G
机构
[1] Tel Aviv Univ, Meir Hosp, Sackler Fac Med, Dept Hypertens & Nephrol, IL-69978 Tel Aviv, Israel
[2] W Virginia Univ, Dept Physiol, Morgantown, WV 26506 USA
[3] Semmelweis Univ, Sch Med, Dept Pathophysiol, Budapest, Hungary
关键词
D O I
10.1016/S0146-0005(99)80055-X
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Some of the maternal symptoms of preeclampsia can be produced by uterine ischemia, although no quadriped spontaneously exhibits this disease. It may be that the combination of upright posture and uteroplacental ischemia are necessary for manifestation of the full syndrome. Chronic nitric oxide synthase inhibition in rats produces a pattern of change that resembles the symptoms of preeclampsia, and the preeclamptic-like response of rats with adriamycin nephropathy and hyperinsulinemia is associated with endothelial dysfunction. These models are definitely of use in preeclampsia research, but because this disease only occurs spontaneously in primates, the definitive studies on preeclampsia will, of necessity, be clinical.
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页码:2 / 13
页数:12
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