Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

被引：227

作者：

Hunger, RE

Sieling, PA

Ochoa, MT

Sugaya, M

Burdick, AE

Rea, TH

Brennan, PJ

Belisle, JT

Blauvelt, A

Porcelli, SA

Modlin, RL

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Dept Med, Los Angeles, CA 90095 USA

[2] NCI, Dermatol Branch, Ctr Canc Res, Bethesda, MD 20892 USA

[3] Miami Univ, Dept Dermatol & Cutaneous Surg, Miami, FL USA

[4] Univ So Calif, Keck Sch Med, Dermatol Sect, Los Angeles, CA USA

[5] Colorado State Univ, Dept Microbiol Immunol & Pathol, Mycobacterial Res Labs, Ft Collins, CO 80523 USA

[6] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA

[7] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA USA

[8] Univ Calif Los Angeles, David Geffen Sch Med, Inst Mol Biol, Los Angeles, CA USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 05期

关键词：

D O I：

10.1172/JCI200419655

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin. Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-specific C-type lectin, imparts a specific functional role to LCs. LC-like DCs and freshly isolated epidermal LCs presented nonpeptide antigens of Mycobacterium leprae to T cell clones derived from a leprosy patient in a CD1a-restricted and langerin-dependent manner. LC-like DCs were more efficient at CD1a-restricted antigen presentation than monocyte-derived DCs. LCs in leprosy lesions coexpress CD1a and langerin, placing LCs in position to efficiently present a subset of antigens to T cells as part of the host response to human infectious disease.

引用

页码：701 / 708

页数：8

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