Neuroendocrine properties of macrophage migration inhibitory factor (MIF)

被引：50

作者：

Fingerle-Rowson, GR ^{[1
]}

Bucala, R ^{[1
]}

机构：

[1] Picower Inst Med Res, Manhasset, NY 11030 USA

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2001年 / 79卷 / 04期

关键词：

brain; cytokine; endotoxemia; glucocorticoids; hypothalamic-pituitary-adrenal axis; insulin; macrophage migration inhibitory factor; neuroendocrine system;

D O I：

10.1046/j.1440-1711.2001.01024.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cytokine macrophage migration inhibitory factor (MIF) is produced by neuroendocrine and immune tissues and possesses several features that allow it to be characterized as a neuroendocrine mediator. Its pro-inflammatory action and its pathogenic role in inflammatory diseases, such as septic shock, arthritis and other diseases, have clearly been demonstrated and may be based in part on neuroendocrine mechanisms. Macrophage migration inhibitory factor possesses glucocorticoid-antagonist properties within the immune system and participates in the regulation of several endocrine circuits. This review summarizes the current state of MIF research and focuses on MIF expression and function in nervous and endocrine tissues.

引用

页码：368 / 375

页数：8

共 83 条

[81] Transcriptional activation of the macrophage migration-inhibitory factor gene by the corticotropin-releasing factor is mediated by the cyclic adenosine 3′,5′-monophosphate responsive element-binding protein CREB in pituitary cells [J].