Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits

被引：10

作者：

Callender, DP

Jayaprakash, N

Bell, A

Petraitis, V

Petratienes, R

Candelario, M

Schaufele, R

Dunn, JM

Sei, S

Walsh, TJ

Balis, FM

机构：

[1] NCI, Pediat Oncol Branch, Bethesda, MD 20892 USA

[2] NCI, HIV & AIDS Malignancy Branch, Bethesda, MD 20892 USA

[3] NCI, Div Clin Sci, Bethesda, MD 20892 USA

[4] Verex Labs Inc, Englewood, CO 80112 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 04期

关键词：

D O I：

10.1128/AAC.43.4.972

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The pharmacokinetic profile of oral zidovudine entrapped in a 50:50 polyactide-coglycolide matrix (nanospheres) was compared to those of standard oral and parenteral zidovudine formulations in rabbits. The bioavailability of zidovudine nanospheres at 50 mg/kg of body weight was 76%, and this dose achieved prolonged exposure to zidovudine compared to standard formulations without an increase in the drug's peak concentration.

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收藏

页码：972 / 974

页数：3

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