A new reagent for solid and solution phase synthesis of protected guanidines from amines

被引：49

作者：

Yong, YF ^{[1
]}

Kowalski, JA ^{[1
]}

Thoen, JC ^{[1
]}

Lipton, MA ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 01期

关键词：

D O I：

10.1016/S0040-4039(98)80017-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new reagent -4-nitro-1-H-pyrazole-1-[N, N'-bis(tert-butoxycarbonyl)]carboxamidine - has been developed to effect the rapid and efficient synthesis of bis(carbamate)-protected guanidines from primary and secondary amines. The reagent is a more electrophilic, and consequently more reactive, derivative of the literature reagent 1-H-pyrazole-1-[N, N'-bis(tert-butoxycarbonyl)]carboxamidine The increased reactivity of the new reagent affords it increased yields in solution and the need for fewer equivalents when guanylating resin-bound amines. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：53 / 56

页数：4

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