Role of adhesion molecules in activation signaling in T lymphocytes

被引：50

作者：

Dustin, ML

机构：

[1] NYU, Sch Med, Skirball Inst Mol Med, Program Mol Pathogenesis,Lab 5, New York, NY 10016 USA

[2] NYU, Sch Med, Skirball Inst Mol Med, Dept Pathol,Lab 5, New York, NY 10016 USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2001年 / 21卷 / 04期

基金：

美国国家卫生研究院;

关键词：

adhesion molecules; activation signaling; T lymphocytes; synapses; cell growth and survival;

D O I：

10.1023/A:1010927208180

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The T cell and antigen-presenting cell communicate to initiate an immune response through formation of an immunological synapse. This specialized cell-cell junction is compartmentalized into adhesion molecule and T cell receptor enriched regions or SMACs. Distinct signals seem to be generated in the T cell receptor and adhesion molecule-dominated regions. This review focuses on how these distinct signaling pathways may be integrated within the T cell to set thresholds for T cell activation, proliferation, and survival.

引用

页码：258 / 263

页数：6

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