The depth of molecular recognition: voltage-sensitive blockage of synthetic multifunctional pores with refined architecture

被引:20
作者
Baudry, Y [1 ]
Pasini, D [1 ]
Nishihara, M [1 ]
Sakai, N [1 ]
Matile, S [1 ]
机构
[1] Univ Geneva, Dept Organ Chem, Geneva, Switzerland
关键词
D O I
10.1039/b509610c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Voltage-sensitive blockage by ADP, ATP and phytate (IP6) demonstrates that active-site contraction toward the middle of newly synthesized rigid-rod beta-barrels provides a general strategy to rationally create and modulate the voltage sensitivity (and to increase the efficiency) of molecular recognition by synthetic multifunctional pores.
引用
收藏
页码:4798 / 4800
页数:3
相关论文
共 29 条
[1]  
BAUFRY Y, 2004, HELV CHIM ACTA, V87, P2181
[2]   p-octiphenyl β-barrels with ion channel and esterase activity [J].
Baumeister, B ;
Sakai, N ;
Matile, S .
ORGANIC LETTERS, 2001, 3 (26) :4229-4232
[3]   Stabilities and isomeric equilibria in aqueous solution of monomeric metal ion complexes of adenosine 5′-diphosphate (ADP3-) in comparison with those of adenosine 5′-monophosphate (AMP2-) [J].
Bianchi, EM ;
Sajadi, SAA ;
Song, B ;
Sigel, H .
CHEMISTRY-A EUROPEAN JOURNAL, 2003, 9 (04) :881-892
[4]   Fluorometric detection of enzyme activity with synthetic supramolecular pores [J].
Das, G ;
Talukdar, P ;
Matile, S .
SCIENCE, 2002, 298 (5598) :1600-1602
[5]   Synthetic models of cation-conducting channels [J].
Gokel, GW ;
Mukhopadhyay, A .
CHEMICAL SOCIETY REVIEWS, 2001, 30 (05) :274-286
[6]   Signal-triggered transmembrane ion transport through synthetic channels [J].
Hector, RS ;
Gin, MS .
SUPRAMOLECULAR CHEMISTRY, 2005, 17 (1-2) :129-134
[7]  
Hille B, 2001, IONIC CHANNELS EXCIT
[8]   Molecular design and synthesis of artificial ion channels based on cyclic peptides containing unnatural amino acids [J].
Ishida, H ;
Qi, Z ;
Sokabe, M ;
Donowaki, K ;
Inoue, Y .
JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (09) :2978-2989
[9]   NMR characterization of complex p-oligophenyl scaffolds by means of aliasing techniques to obtain resolution-enhanced two-dimensional spectra [J].
Jeannerat, D ;
Ronan, D ;
Haudry, Y ;
Pinto, A ;
Saulnier, JP ;
Matile, S .
HELVETICA CHIMICA ACTA, 2004, 87 (09) :2190-2207
[10]   Artificial ion channel formed by cucurbit[n]uril derivatives with a carbonyl group fringed portal reminiscent of the selectivity filter of K+ channels [J].
Jeon, YJ ;
Kim, H ;
Jon, S ;
Selvapalam, N ;
Oh, DH ;
Seo, I ;
Park, CS ;
Jung, SR ;
Koh, DS ;
Kim, K .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (49) :15944-15945