Brain-derived neurotrophic factor: findings in schizophrenia

被引：115

作者：

Buckley, Peter F. ^{[1
]}

Pillai, Anilkumar ^{[1
]}

Howell, Kristy R. ^{[1
]}

机构：

[1] Med Coll Georgia, Dept Psychiat & Hlth Behav, Augusta, GA 30912 USA

来源：

CURRENT OPINION IN PSYCHIATRY | 2011年 / 24卷 / 02期

关键词：

antipsychotic; brain-derived neurotrophic factor; neuroplasticity; peripheral; psychosis; schizophrenia; Val66Met; LONG-TERM POTENTIATION; CULTURED HIPPOCAMPAL-NEURONS; FACTOR VAL66MET POLYMORPHISM; SERUM BDNF LEVELS; BIPOLAR DISORDER; CONTROLLED-TRIAL; TRKB RECEPTORS; PREFRONTAL CORTEX; DECREASED LEVELS; FACTOR PROMOTES;

D O I：

10.1097/YCO.0b013e3283436eb7

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

Purpose of review To review the role of brain-derived neurotrophic factor (BDNF) in neuroplasticity related to schizophrenia and the recent findings that have been reported on the status of BDNF in patients with schizophrenia and its association with the clinical measures. Recent findings Peripheral BDNF levels have been found altered in first-episode patients with psychosis and also in chronic schizophrenia patients. A few studies have reported changes in peripheral BDNF levels following antipsychotic treatment. The role of Val66Met polymorphism in BDNF has been shown to play an important role in structural and functional plasticity in schizophrenia. Summary Although peripheral BDNF levels hold promise for providing new perspectives for the development of novel therapeutic strategies for the treatment of schizophrenia, additional studies including efforts to prove its potential as a biomarker are warranted.

引用

页码：122 / 127

页数：6

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